Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver

The effects of two oleic-acid-rich diets (containing olive oil, OO, and high-oleic-acid sunflower oil, HOSO) on plasma and liver lipid composition detoxification enzyme activities, were compared with those of a fish-oil (FO) diet and a control diet. Compared with the control diet, plasma and hepatic...

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Published in:British journal of nutrition 1999-09, Vol.82 (3), p.233-241
Main Authors: Ruiz-Gutiérrez, Valentina, Pérez-Espinosa, Alonso, Vázquez, Carmen María, Santa-María, Consuelo
Format: Article
Language:English
Subjects:
Analysis of Variance
animal models
Animals
Antioxidant enzymes
antioxidants
Antioxidants - analysis
Antioxidants - metabolism
Biological and medical sciences
blood lipids
blood plasma
catalase
Catalase - analysis
Catalase - metabolism
cholesterol
diet
dietary fat
Dietary Fats, Unsaturated - administration & dosage
Dietary Fats, Unsaturated - metabolism
enzyme activity
experimental diets
Fatty acids
fish oils
Fish Oils - administration & dosage
Fundamental and applied biological sciences. Psychology
glutathione peroxidase
Glutathione Peroxidase - analysis
Glutathione Peroxidase - metabolism
Helianthus
lipids
Lipids - blood
Lipids - chemistry
liver
Liver - enzymology
Liver - metabolism
Liver. Bile. Biliary tracts
Male
NADPH-cytochrome-c2 reductase
nutrient intake
Oleic acid
Oleic Acid - administration & dosage
Oleic Acid - metabolism
Olive Oil
phospholipids
Plant Oils - administration & dosage
Random Allocation
Rats
Rats, Wistar
Sunflower Oil
superoxide dismutase
Superoxide Dismutase - analysis
Superoxide Dismutase - metabolism
triacylglycerols
Vertebrates: digestive system
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Summary:The effects of two oleic-acid-rich diets (containing olive oil, OO, and high-oleic-acid sunflower oil, HOSO) on plasma and liver lipid composition detoxification enzyme activities, were compared with those of a fish-oil (FO) diet and a control diet. Compared with the control diet, plasma and hepatic total triacylglycerol concentrations were increased in the animals fed on the HOSO and OO diets and decreased in those fed on the FO diet. The animals fed on FO showed the highest level of cholesterol in the liver and had lower plasma cholesterol concentrations when compared with those fed on the two oleic-acid-rich diets. In comparison with the animals fed on the diets enriched in oleic acid, the FO group showed higher hepatic levels of polyunsaturated fatty acids of the n-3 series and lower levels of fatty acids of the n-6 series. Livers of FO-fed rats, compared with those of OO- and HOSO-fed rats showed: (1) significantly higher activities of catalase (EC 1.11.1.6) glutathione peroxidase (EC 1.11.1.9) and Cu/Zn superoxide dismutase (EC 1.15.1.1); (2) no differences in the NADPH-cytochrome c reductase (EC 1.6.99.3) activity. The HOSO diet had a similar effect on liver antioxidant enzyme activities as the OO diet. In conclusion, it appears that changes in the liver fatty acid composition due mainly to n-3 lipids may enhance the efficiency of the antioxidant defence system. The two monounsaturated fatty acids oils studied (OO and HOSO), with the same high content of oleic acid but different contents of natural antioxidants, had similar effects on the antioxidant enzyme activities measured.
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114599001415