The influence of polymorphism of −493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress

The aim of this study was to investigate the effect of the microsomal triglyceride transfer protein (MTP) −493G/T polymorphism on clinical and biochemical parameters in relation to the presence of metabolic syndrome (MS). A group of 270 participants, 143 men and 127 women [50 men/36 women fulfilled...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2008-09, Vol.19 (9), p.634-641
Main Authors: Žák, Aleš, Jáchymová, Marie, Tvrzická, Eva, Vecka, Marek, Duffková, Ladislava, Zeman, Miroslav, Slabý, Adolf, Staňková, Barbora
Format: Article
Language:English
Subjects:
adults
alleles
Atherogenic dyslipidemia
Biological and medical sciences
blood chemistry
Blood Glucose - metabolism
blood lipids
Carrier Proteins - genetics
fatty acid composition
Fatty acid profile
Fatty Acids - blood
Feeding. Feeding behavior
Female
free fatty acids
Fundamental and applied biological sciences. Psychology
genetic polymorphism
Homeostasis
homozygosity
Humans
insulin
insulin resistance
Insulin Resistance - genetics
Lipid Metabolism - genetics
Lipoproteins, LDL - metabolism
low density lipoprotein
Male
men
Metabolic syndrome
Metabolic Syndrome - physiopathology
Microsomal triglyceride transfer protein
microsomes
molecular sequence data
omega-6 fatty acids
Oxidative stress
Oxidative Stress - physiology
oxygenases
Polymorphism, Genetic
promoter regions
Promoter Regions, Genetic - genetics
Sex Factors
transport proteins
triacylglycerols
Vertebrates: anatomy and physiology, studies on body, several organs or systems
women
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Summary:The aim of this study was to investigate the effect of the microsomal triglyceride transfer protein (MTP) −493G/T polymorphism on clinical and biochemical parameters in relation to the presence of metabolic syndrome (MS). A group of 270 participants, 143 men and 127 women [50 men/36 women fulfilled the International Diabetes Federation (IDF) criteria of MS], was categorized on the basis of the MTP −493G/T polymorphism: GG homozygotes (Group GG) and carriers of the T allele (Group TT+TG). In men with MS, the presence of the T allele was associated with elevated concentrations of plasma insulin (by 48%, P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2007.09.001