Interaction between dopamine and glutamate receptors following treatment with NMDA receptor antagonists

Interactions between dopamine and glutamate neurotransmission have been reported to play an important role in a number of different systems. We were interested in examining the effects of sub-chronic treatment with NMDA receptor antagonists (dizocilpine [MK-801], and 3-carboxy-piperazin-propyl phosp...

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Bibliographic Details
Published in:European journal of pharmacology 1999-12, Vol.386 (2), p.155-163
Main Authors: Vasiliadis, Helen-Maria, Élie, Robert, Dewar, Karen M
Format: Article
Language:English
Subjects:
6-Hydroxydopamine
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism
Animals
Benzamides - pharmacology
Benzazepines - pharmacology
Biological and medical sciences
Dizocilpine Maleate - pharmacology
Dopamine Antagonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Female
Glutamatergic system (aspartate and other excitatory aminoacids)
Ligand binding autoradiography
Medical sciences
Neostriatum
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Oxidopamine - pharmacology
Pharmacology. Drug treatments
Piperazines - pharmacology
Rats
Rats, Sprague-Dawley
Receptor Cross-Talk
Receptors, AMPA - metabolism
Receptors, Dopamine - metabolism
Receptors, Glutamate - metabolism
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Substantia nigra
Tritium
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Summary:Interactions between dopamine and glutamate neurotransmission have been reported to play an important role in a number of different systems. We were interested in examining the effects of sub-chronic treatment with NMDA receptor antagonists (dizocilpine [MK-801], and 3-carboxy-piperazin-propyl phosphonic acid [CPP]) on dopamine D 1-like, dopamine D 2-like, as well as glutamate receptors of the NMDA and AMPA receptor subtypes in the neostriatum and substantia nigra of rats that had received a massive dopamine denervation at 3 days of age. Using quantitative ligand binding autoradiography, we demonstrated that the two NMDA receptor antagonists did not have different profiles of action. Furthermore, while we found a significant negative relationship between NMDA receptors and dopamine receptors (both dopamine D 1-like and D 2-like receptor subtypes) in the neostriatum, AMPA receptors were positively correlated with dopamine D 1-like binding sites in all regions investigated. These findings suggest that the interrelationship between dopamine and glutamate receptors is highly controlled and that the nigrostriatal dopamine systems play an important role in this interaction.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00770-0