Assessment of Culprit and Remote Coronary Narrowings Using Optical Coherence Tomography With Long-Term Outcomes

Much currently known information about vulnerable plaque stems from postmortem studies that identified several characteristics making them prone to rupture, including the presence of a thin fibrous cap and a large lipid core. This study used optical coherence tomography (OCT) to assess culprit and r...

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Bibliographic Details
Published in:	The American journal of cardiology 2008-08, Vol.102 (4), p.391-395
Main Authors:	Barlis, Peter, MBBS, MPH, Serruys, Patrick W., MD, PhD, Gonzalo, Nieves, MD, van der Giessen, Willem J., MD, PhD, de Jaegere, Peter J., MD, PhD, Regar, Evelyn, MD, PhD
Format:	Article
Language:	eng
Subjects:	Aged Angioplasty, Balloon, Coronary Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Clinical medicine Clinical outcomes Coronary Artery Disease - diagnosis Coronary Artery Disease - pathology Coronary heart disease Coronary vessels Coronary Vessels - pathology Female Heart Humans Lipids Male Medical sciences Middle Aged Pilot Projects Retrospective Studies Severity of Illness Index Stroke Volume Time Factors Tomography Tomography, Optical Coherence - instrumentation Treatment Outcome
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Summary:	Much currently known information about vulnerable plaque stems from postmortem studies that identified several characteristics making them prone to rupture, including the presence of a thin fibrous cap and a large lipid core. This study used optical coherence tomography (OCT) to assess culprit and remote coronary narrowings and investigate whether intracoronary OCT in living patients was able to visualize morphologic features associated with vulnerable plaque in postmortem studies. Twenty-three patients successfully underwent OCT before percutaneous coronary intervention. The culprit lesion and mild to moderate coronary narrowings remote from the target stenosis were investigated. Using OCT, the culprit lesion was found to be fibrous in 39.1%, fibrocalcific in 34.4%, and lipid rich in 26.1% of cases. Two patients met criteria for thin-cap fibroatheroma (TCFA; defined as the presence of a signal-rich fibrous cap covering a signal-poor lipid/necrotic core with cap thickness
ISSN:	0002-9149 1879-1913