Dose response and organ invasion of day-of-hatch Leghorn chicks by different isolates of Campylobacter jejuni

Colonization of the ceca and organ invasion by different isolates of Campylobacter jejuni were investigated in day-of-hatch leghorn chicks. This model of Campylobacter colonization of the ceca demonstrates that 1) day-of-hatch birds do not naturally contain cecal Campylobacter, 2) ceca can be coloni...

Full description

Saved in:
Bibliographic Details
Published in:Avian diseases 1999-10, Vol.43 (4), p.763-767
Main Authors: Young, C.R, Ziprin, R.L, Hume, M.E, Stanker, L.H
Format: Article
Language:English
Subjects:
Animal models
Animals
application rate
Campylobacter
Campylobacter Infections - physiopathology
Campylobacter Infections - transmission
Campylobacter Infections - veterinary
Campylobacter jejuni
Campylobacter jejuni - classification
Campylobacter jejuni - isolation & purification
Campylobacter jejuni - pathogenicity
cecum
Cecum - microbiology
Chickens
Chicks
Cloaca
colonization
colonizing ability
Diarrhea
Disease models
dosage
Dose response relationship
Gavage
Humans
Inoculation
invasion
liver
Microbial colonization
Poultry Diseases - microbiology
Poultry Diseases - physiopathology
Poultry Diseases - transmission
Research Notes
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Colonization of the ceca and organ invasion by different isolates of Campylobacter jejuni were investigated in day-of-hatch leghorn chicks. This model of Campylobacter colonization of the ceca demonstrates that 1) day-of-hatch birds do not naturally contain cecal Campylobacter, 2) ceca can be colonized with C. jejuni by oral gavage and not by cloacal inoculation; 3) C. jejuni can be recovered from the ceca up until at least 7 days postinoculation, 4) cecal colonization occurs when as little as 10(2) colony-forming units is orally inoculated into chicks, and 5) different C. jejuni isolates vary both in their ability to colonize the ceca and in their ability to invade the liver. These studies demonstrate that we have a working animal model for Campylobacter colonization for day-of-hatch chicks. This animal model is being used to examine intervention strategies such as vaccines by which Campylobacter can be reduced or removed from the food animal.
ISSN:0005-2086
1938-4351
DOI:10.2307/1592745