Birth weight is lower for survivors of the vanishing twin syndrome: a case-control study

Objective To compare the outcome of singleton pregnancies originating from a twin gestation with singleton pregnancies originating from a single gestation. Design Case-control study. Setting Women's general hospital in Austria. Patient(s) A total of 794 singleton deliveries after IVF/intracytop...

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Bibliographic Details
Published in:Fertility and sterility 2008-08, Vol.90 (2), p.310-314
Main Authors: Shebl, Omar, M.D, Ebner, Thomas, Ph.D, Sommergruber, Michael, M.D, Sir, Andreas, M.D, Tews, Gernot, M.D
Format: Article
Language:English
Subjects:
Abortion, Missed
Adult
Biological and medical sciences
Birth Weight
Case-Control Studies
Diseases in Twins
Diseases of mother, fetus and pregnancy
Female
Fertilization in Vitro - adverse effects
Fetal Resorption
Gynecology. Andrology. Obstetrics
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Small for Gestational Age
Internal Medicine
IVF/ICSI
Medical sciences
Obstetrics and Gynecology
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple
Pregnancy. Fetus. Placenta
singleton pregnancies
small for gestational age
Sperm Injections, Intracytoplasmic - adverse effects
spontaneous abortion
Twins
Vanishing twin syndrome
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Summary:Objective To compare the outcome of singleton pregnancies originating from a twin gestation with singleton pregnancies originating from a single gestation. Design Case-control study. Setting Women's general hospital in Austria. Patient(s) A total of 794 singleton deliveries after IVF/intracytoplasmic sperm injection, including 46 survivors of vanishing twin syndrome (study group) and 92 matched singletons (control group). Intervention(s) None. Main Outcome Measure(s) Data concerning duration of gestation, mode of delivery, birth weight, neonatal intensive care unit admission, duration of hospitalization, perinatal mortality. Result(s) Of all singletons born, 5.8% originated from a twin gestation. Mean (± SD) birth weight was significantly higher in the control group (2876.3 ± 600.5 g vs. 3249.6 ± 624.5 g). The frequency of low birth weight (26.1% vs. 12.0%) and being small for gestational age (32.6% vs. 16.3%) was significantly lower in the control group. No differences were observed in terms of duration of gestation. Conclusion(s) A higher risk for lower birth weight and being small for gestational age for survivors of the vanishing twin syndrome was found. Such pregnancies need to be carefully monitored, and parents must be informed about the associated risks when transferring more than one embryo.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2007.06.048