Specificities of Multiple Sclerosis Cerebrospinal Fluid and Serum Antibodies against Mimotopes

In order to characterize antigenic epitopes specifically targeted by the immune response of patients with multiple sclerosis (MS), the antibody specificities of cerebrospinal fluids (CSF) and sera from the same MS patients have been analyzed using a random pentadecapeptide library displayed on phage...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 1999-12, Vol.93 (3), p.283-293
Main Authors: Jolivet-Reynaud, Colette, Perron, Hervé, Ferrante, Pasquale, Becquart, Laurence, Dalbon, Pascal, Mandrand, Bernard
Format: Article
Language:English
Subjects:
Amino Acid Sequence
antibodies
Antibodies - blood
Antibodies - cerebrospinal fluid
Antibodies - immunology
Antibody Affinity
Antibody Specificity - immunology
Bacteriophages - immunology
Binding Sites, Antibody
Biological and medical sciences
CSF
epitopes
Epitopes - immunology
Humans
Medical sciences
Molecular Mimicry
multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - diagnosis
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Oligopeptides - immunology
peptides
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Summary:In order to characterize antigenic epitopes specifically targeted by the immune response of patients with multiple sclerosis (MS), the antibody specificities of cerebrospinal fluids (CSF) and sera from the same MS patients have been analyzed using a random pentadecapeptide library displayed on phage. The 3 peptides (mimotopes) selected with MS sera were not disease-specific. In contrast, the combination of 4 MS CSF selected mimotopes, allowed the detection of specific antibodies in 21 of 60 MS CSF whereas only 2 of 27 CSF from patients with other neurological diseases equally recognized the 4 mimotopes. Some amino acid similarities were found between two MS CSF selected mimotopes and two envelope regions (319–329 and 433–443, respectively) of MSRV (multiple-sclerosis-associated retrovirus) and the related endogenous retrovirus HERV-W.
ISSN:1521-6616
1521-7035
DOI:10.1006/clim.1999.4789