Mechanical properties of rat thoracic and abdominal aortas

Abstract Mechanical properties of abdominal and thoracic arteries of 2 mm in diameter were determined from adults Wistar rats. A tensile testing instrument was used to obtain stress/strain curves with arteries immersed in physiological buffer at 37 °C. A displacement was applied on all arteries with...

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Bibliographic Details
Published in:Journal of biomechanics 2008-07, Vol.41 (10), p.2227-2236
Main Authors: Assoul, N, Flaud, P, Chaouat, M, Letourneur, D, Bataille, I
Format: Article
Language:English
Subjects:
Abdomen
Algorithms
Animals
Aorta, Abdominal - anatomy & histology
Aorta, Abdominal - pathology
Aorta, Thoracic - anatomy & histology
Aorta, Thoracic - pathology
Biomechanical Phenomena - methods
Biomechanics
Collagen
Coronary vessels
Design
Equipment Design
Laboratory animals
Male
Mathematical models
Mechanical properties
Models, Biological
Models, Statistical
Mortality
Physical Medicine and Rehabilitation
Prostheses
Rat arteries
Rats
Rats, Wistar
Rodents
SDS/Triton treatment
Smooth muscle
Stress, Mechanical
Temperature
Tensile Strength
Tensile tests
Time Factors
Tissue engineering
Veins & arteries
Young modulus
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Summary:Abstract Mechanical properties of abdominal and thoracic arteries of 2 mm in diameter were determined from adults Wistar rats. A tensile testing instrument was used to obtain stress/strain curves with arteries immersed in physiological buffer at 37 °C. A displacement was applied on all arteries with various frequencies (1–7.5 Hz) and strains (5–60%). From each curve a Young modulus was obtained using a mathematical model based on a nonlinear soft tissue model. No influence of frequency on modulus was evidenced in the tested range. Abdominal aortas, which were found slightly thicker than thoracic aortas, were characterized by a higher modulus. Due to the interest of decellularized biological materials, we also used SDS/Triton treated arteries, and found that the chemical treatment increased modulus of thoracic arteries. Tensile tests were also performed on thoracic aortas in the longitudinal and transversal directions. Longitudinal moduli were found higher than transversal moduli and the difference could be related to the longitudinal orientation of collagen fibers. These data and mathematical model seem useful in the design of new vascular synthetic or biological prostheses for the field of tissue engineering.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2008.04.017