Excellent prognosis and prevalence of HCV infection of primary hepatic and splenic non-Hodgkin's lymphoma

Background:  Primary Hepatic (PHL) and Primary Splenic (PSL) non‐Hodgkin’s Lymphoma are rare entities. Small series of PHL and PSL have been reported, suggesting a non‐fortuitous association with Hepatitis C Virus (HCV) infection. The prognosis is believed to be dismal, with early recurrence and sho...

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Published in:European journal of haematology 2008-07, Vol.81 (1), p.51-57
Main Authors: De Renzo, Amalia, Perna, Fabiana, Persico, Marcello, Notaro, Rosario, Mainolfi, Ciro, De Sio, Ilario, Ciancia, Giuseppe, Picardi, Marco, Del Vecchio, Luigi, Pane, Fabrizio, Rotoli, Bruno
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Female
Follow-Up Studies
Hepatitis C - complications
Hepatitis C virus
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - etiology
Liver Neoplasms - virology
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - etiology
Lymphoma, Non-Hodgkin - virology
Male
Middle Aged
Prevalence
primary hepatic lymphoma
primary splenic lymphoma
Prognosis
Recurrence
Remission Induction
Retrospective Studies
Splenic Neoplasms - drug therapy
Splenic Neoplasms - etiology
Splenic Neoplasms - virology
Survival Rate
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Summary:Background:  Primary Hepatic (PHL) and Primary Splenic (PSL) non‐Hodgkin’s Lymphoma are rare entities. Small series of PHL and PSL have been reported, suggesting a non‐fortuitous association with Hepatitis C Virus (HCV) infection. The prognosis is believed to be dismal, with early recurrence and short survival. Patients:  We retrospectively reviewed all PHL and PSL patients diagnosed at our institution between 1990 and 2005. Results:  Twenty‐five adult patients were identified, six with PHL and 19 with PSL. Twenty‐four patients had a B‐cell lymphoma, defined as Diffuse Large B‐cell lymphoma in 18. The prevalence of HCV infection was 68% among PSL and 66% among PHL. Combination chemotherapy was the mainstay of treatment for PHL and PSL; all but one patient with PSL underwent splenectomy before chemotherapy. Complete remission was achieved in all the cases after frontline therapy; only four patients relapsed but responded to additional chemotherapy courses. Most patients presented with aggressive histological subtypes; 92% were alive at a median follow up of 79 months. HCV infection did not appear to influence the results of therapy. Conclusion:  Our study confirms the rarity of PHL and PSL, shows a high prevalence of HCV infection, and demonstrates that the outcome of patients with PHL and PSL may be favourable.
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2008.01081.x