First detection of enterovirus 71 from an acute flaccid paralysis case with residual paralysis in Iran

Abstract In an attempt to determine the types of non-polio enteroviruses (NPEVs) in acute flaccid paralysis (AFP) cases in Iran, we detected enterovirus 71 (EV71) in an AFP case with residual paralysis for the first time. Cell culture detected no enteroviruses, while RT-PCR and subsequent sequencing...

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Bibliographic Details
Published in:Journal of clinical virology 2008-08, Vol.42 (4), p.409-411
Main Authors: Shahmahmoodi, Shohreh, Mehrabi, Zahra, Eshraghian, Mohammad Reza, Azad, Talat Mokhtari, Tabatabaie, Hamideh, Yousefi, Maryam, Farrokhi, Kobra, Gouya, Mohammad Mehdi, Esteghamati, Abolreza, Moosavi, Taha, Zahraie, Mohsen, Rad, Katayoon Samimi, Shokati, Zahra, Nategh, Rakhshandeh
Format: Article
Language:English
Subjects:
Acute flaccid paralysis (AFP)
Adolescent
Allergy and Immunology
Biological and medical sciences
Enterovirus
Enterovirus 71 (EV71)
Enterovirus A, Human - isolation & purification
Enterovirus Infections - complications
Enterovirus Infections - virology
Female
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infectious Disease
Infectious diseases
Iran
Medical sciences
Microbiology
Miscellaneous
Muscle Hypotonia
Non-polio enterovirus (NPEV)
Paralysis
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - genetics
RT-seminested PCR (RT-snPCR)
Sequence Analysis, DNA
Viral diseases
Viral diseases of the nervous system
Virology
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Summary:Abstract In an attempt to determine the types of non-polio enteroviruses (NPEVs) in acute flaccid paralysis (AFP) cases in Iran, we detected enterovirus 71 (EV71) in an AFP case with residual paralysis for the first time. Cell culture detected no enteroviruses, while RT-PCR and subsequent sequencing revealed that the specimen was positive for EV71. EV71 is the causative agent of a variety of diseases from hand, foot and mouth disease to severe neurological complications and is now considered as an important cause of childhood acute flaccid paralysis.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2008.02.013