Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: Report of a case

We report a case of a granular cell tumor (GCT) covered by squamous cell carcinoma (SCC) in the esophagus. A 69-year-old Japanese man was admitted to our hospital for treatment of superficial esophageal cancer detected by upper gastrointestinal endoscopy. Endoscopic examination revealed a shallow ul...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2008-07, Vol.38 (7), p.651-655
Main Authors: Saito, Kana, Kato, Hiroyuki, Fukai, Yasuyuki, Kimura, Hitoshi, Miyazaki, Tatsuya, Kashiwabara, Kenji, Nakajima, Takashi, Kuwano, Hiroyuki
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Case Report
Endoscopy, Gastrointestinal
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Granular Cell Tumor - pathology
Granular Cell Tumor - surgery
Humans
Incidental Findings
Male
Medicine
Medicine & Public Health
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
Surgery
Surgical Oncology
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Summary:We report a case of a granular cell tumor (GCT) covered by squamous cell carcinoma (SCC) in the esophagus. A 69-year-old Japanese man was admitted to our hospital for treatment of superficial esophageal cancer detected by upper gastrointestinal endoscopy. Endoscopic examination revealed a shallow ulcer in the esophagus, 28–32 cm from the incisor teeth. The pathological findings of a biopsy of the lesion were moderately differentiated SCC. Thus, we performed partial esophagectomy with two-field (thoraco-abdominal) lymph node dissection. Microscopic examination of the surgical specimen revealed intraepithelial SCC with minimal invasion, and a GCT, 3 × 1 mm in size, in the submucosa just beneath the SCC. Cytoplasmic granules in the GCT were positive for periodic acid-Schiff. Immunohistochemically, the GCT was strongly positive for S-100 protein. To our knowledge, this is the first published report of a GCT covered by SCC in the esophagus.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-007-3694-2