Pharmacokinetic study of stobadine

The aim of this paper is to provide a brief overview of most important results of stobadine kinetic studies in rats, dogs, and human volunteers. In these studies, stobadine dihydrochloride and stobadine dipalmitate was used for intravenous and oral administration, respectively. To evaluate kinetic p...

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Bibliographic Details
Published in:Life sciences (1973) 1999-10, Vol.65 (18), p.2003-2005
Main Authors: Bezek, Š., Šortés, L., Ščasnár, V., Bauerová, K., Kállay, Z., Ďurišová, M., Mihalová, D., Bohov, P., Faberová, V., Kukan, M., Trnovec, T., Koprda, V.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacokinetics
antioxidative agent
Area Under Curve
Carbolines - pharmacokinetics
Dogs
Gas Chromatography-Mass Spectrometry
Half-Life
Humans
Intestinal Absorption
pharmacokinetics
Rats
stobadine
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Summary:The aim of this paper is to provide a brief overview of most important results of stobadine kinetic studies in rats, dogs, and human volunteers. In these studies, stobadine dihydrochloride and stobadine dipalmitate was used for intravenous and oral administration, respectively. To evaluate kinetic properties of stobadine and its metabolites, TLC, HPLC, GLC, GC-MS, radiometric, and fluorometric methods were developed and used.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(99)00465-8