Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure The Danish Stem Cell study-Congestive Heart Failure trial (DanCell-CHF)

Background: It has been suggested that myocardial regeneration may be achieved by a single intracoronary bone marrow derived stem cell infusion in selected patients with ischaemic heart disease. The effect is uncertain in patients with chronic ischaemic heart failure and it is not known whether repe...

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Bibliographic Details
Published in:European journal of heart failure 2008-07, Vol.10 (7), p.661-667
Main Authors: Diederichsen, Axel C.P., Møller, Jacob E., Thayssen, Per, Junker, Anders B., Videbæk, Lars, Sækmose, Susanne G., Barington, Torben, Kristiansen, Malthe, Kassem, Moustapha
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analysis of Variance
Denmark
Echocardiography
Exercise Test
Female
Heart Failure - physiopathology
Heart Failure - therapy
Humans
Ischaemic heart failure
Left ventricular ejection fraction
Male
Middle Aged
Myocardial Ischemia - physiopathology
Myocardial Ischemia - therapy
Prospective Studies
Stem cell therapy
Stem Cell Transplantation - methods
Systole
Transplantation, Autologous
Treatment Outcome
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
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Summary:Background: It has been suggested that myocardial regeneration may be achieved by a single intracoronary bone marrow derived stem cell infusion in selected patients with ischaemic heart disease. The effect is uncertain in patients with chronic ischaemic heart failure and it is not known whether repeated infusions would have additional positive effects. Aims: To assess whether two treatments of intracoronary infusion of bone marrow stem cells, administered 4 months apart, could improve left ventricular (LV) systolic function in patients with chronic ischaemic heart failure. Methods: The study was prospective and non-randomised, comprising an observational baseline period of 4 months followed by an interventional period of 12 months. Intracoronary bone marrow cell infusion was performed at the end of the baseline period and repeated 4 months later. Results: 32 patients were included. LV ejection fraction remained unchanged (33±9% vs. 34±10% after 8 months, p=0.30). Likewise, there was no significant change in LV end-systolic volume, wall motion score index (WMSI) or contractile reserve. At 12 months, a decrease in target vessel WMSI was seen (2.17±0.34 vs. 2.06±0.46, p=0.02). Furthermore, NYHA class improved (p
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2008.05.010