Rectal and colonic mesalazine concentration in ulcerative colitis: oral vs. oral plus topical treatment

Aim : To measure mucosal concentrations of mesalazine in ulcerative colitis patients treated with oral mesalazine alone, compared to patients treated with both topical and oral mesalazine. Methods : Twenty‐two patients with mild to moderate ulcerative colitis were randomized to receive 2.4 g/day of...

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Published in:Alimentary pharmacology & therapeutics 1999-11, Vol.13 (11), p.1413-1417
Main Authors: FRIERI, G, PIMPO, M. T, PALUMBO, G. C, ONORI, L, VISCIDO, A, LATELLA, G, GALLETTI, B, PANTALEONI, G. C, CAPRILLI, R
Format: Article
Language:English
Subjects:
Administration, Oral
Administration, Topical
Adult
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Biological and medical sciences
Colitis, Ulcerative - metabolism
Colon - metabolism
Colonoscopy
Digestive system
Female
Humans
Intestinal Mucosa - metabolism
Male
Medical sciences
Mesalamine - administration & dosage
Mesalamine - pharmacokinetics
Middle Aged
Pharmacology. Drug treatments
Rectum - metabolism
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Summary:Aim : To measure mucosal concentrations of mesalazine in ulcerative colitis patients treated with oral mesalazine alone, compared to patients treated with both topical and oral mesalazine. Methods : Twenty‐two patients with mild to moderate ulcerative colitis were randomized to receive 2.4 g/day of oral mesalazine (11 patients) or 2.4 g/day oral plus 4 g/day of topical mesalazine (11 patients). After 2 weeks of treatment, endoscopic biopsies specimens were taken from the rectum and in descending colon just distal of the splenic flexure and stored to –80 °C for later assay (HPLC). Wilcoxon’s rank sum test for unpaired data was used for the statistical analysis. Results : Mucosal levels of mesalazine in the rectum were significantly higher in patients who received oral plus topical treatment than in those who had oral treatment alone (52.1 ng/mg, range: 13.6–122.1 vs. 0.2 ng/mg, range: 0.2–9.7, respectively; P 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.1999.00642.x