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Effects of Liquid DL-2-Hydroxy-4-Methylthio Butanoic Acid on Growth Performance and Immune Responses in Broiler Chickens
An experiment was conducted to determine the effects of different doses of liquid DL-2-hydroxy-4-methylthio butanoic acid (LMA) on growth performance and immune response in broiler chickens. In an arrangement with 4 graded levels of LMA to meet 80, 100, 120, and 140% of methionine requirements of br...
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Published in: | Poultry science 2008-07, Vol.87 (7), p.1370-1376 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | An experiment was conducted to determine the effects of different doses of liquid DL-2-hydroxy-4-methylthio butanoic acid (LMA) on growth performance and immune response in broiler chickens. In an arrangement with 4 graded levels of LMA to meet 80, 100, 120, and 140% of methionine requirements of broilers recommended by Chinese feeding standards for chickens, 256 one-day-old Arbor Acres male broiler chickens were randomly divided into 4 treatments with 8 replicates of 8 birds each. Growth performance, cellular immunity, and humoral immunity were determined. Results from increasing LMA levels were as follows. There were no significant differences (P > 0.05) in body weight gain and feed intake among the treatments, but the ratio of feed to gain was linearly decreased and significantly greatest (P < 0.05) in the group fed at 80% of methionine requirement. Serum globulin levels on d 21 and 42 were linearly increased significantly (P < 0.05); phagocytosis of neutral red of peripheral blood lymphocyte was quadratic and was lowest in the deficient group (P < 0.05). The proliferation of peripheral blood lymphocytes in response to lipopolysaccharide was quadratically influenced, and that of the 120% group on d 21 and the 100% group on d 42 was significantly greater than in the other groups (P < 0.05). Antibody titers to Newcastle disease virus on d 4 after the first inoculation of the vaccine were quadratically increased, anti-bovine serum albumin antibody production on d 13 after the second immunization was quadratic, and antibody titers were greatest in the groups fed at 100 or 120% of methionine requirement. In conclusion, methionine deficiency resulted in decreased feed utilization and decreased humoral and nonspecific immuno-competence of broiler chickens. The use of LMA to correct a methionine deficiency corrected these problems. |
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ISSN: | 0032-5791 1525-3171 |
DOI: | 10.3382/ps.2007-00366 |