Comparison of Fick and thermodilution cardiac output determinations in standing horses

The Fick and thermodilution (TD) methods are two currently popular techniques for determination of cardiac output (CO) in adult horses. To our knowledge, a comparison of these two techniques has not been reported. Six healthy, resting, fit, adult horses of either sex and weighing 516.5 ± 33.2 kg (me...

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Bibliographic Details
Published in:Research in veterinary science 2008-10, Vol.85 (2), p.307-314
Main Authors: Lépiz, Mauricio Loría, Keegan, Robert D., Bayly, Warwick M., Greene, Stephen A., McEwen, Margaret-Mary
Format: Article
Language:English
Subjects:
Agreements
Animals
blood flow
Cardiac output
Cardiac Output - physiology
catecholamines
Catheters
Clinical medicine
Dobutamine
Female
Fick method
Fick principle
Fitness equipment
Gases
Horses
Horses - physiology
Indicator Dilution Techniques - veterinary
Intubation
Laboratory animals
Male
Measurement techniques
Methods
physiological regulation
posture
Studies
Thermodilution
thermodilution cardiac output
Veins & arteries
Veterinary medicine
Xylazine
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Summary:The Fick and thermodilution (TD) methods are two currently popular techniques for determination of cardiac output (CO) in adult horses. To our knowledge, a comparison of these two techniques has not been reported. Six healthy, resting, fit, adult horses of either sex and weighing 516.5 ± 33.2 kg (mean ± SD) were instrumented to enable measurement of cardiac output. Resting CO was determined by the Fick method and by thermodilution while the horses stood quietly in the stocks. Fick and thermodilution CO measurements were repeated under conditions of increased cardiac output achieved with the use of a dobutamine infusion (5 μg kg −1 min −1, IV), and again under conditions of decreased CO induced by administration of xylazine (0.5 mg/kg, IV). Fick and thermodilution cardiac outputs were compared using Bland–Altman analysis for repeated measures. The mean of the differences ± 1.96SD (bias and precision) between the two techniques was 1.88 ± 24.17 L/min. Variability between measurements with the two techniques was decreased to 3.41 ± 46.78 mL kg −1 min −1 when CO was normalized for body size by calculation of cardiac index.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2007.10.013