Frontal lobe structure and executive function in migraine patients

Neuroimaging studies have identified frontal lobe brain abnormalities in migraineurs. Neuropsychological investigations highlighted frontal lobe related cognitive impairments in migraineurs, including working memory and executive function deficits. The relationship between brain anatomy and cognitiv...

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Bibliographic Details
Published in:Neuroscience letters 2008-08, Vol.440 (2), p.92-96
Main Authors: Schmitz, Nicole, Arkink, Enrico B., Mulder, Marieke, Rubia, Katya, Admiraal-Behloul, Faiza, Schoonmann, Guus G., Kruit, Mark C., Ferrari, Michel D., van Buchem, Mark A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Cognition - physiology
Executive function
Female
Frontal cortex
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI)
Memory - physiology
Middle Aged
Migraine
Migraine Disorders - pathology
Migraine Disorders - physiopathology
Migraine Disorders - psychology
Neuropsychological Tests - statistics & numerical data
Psychomotor Performance - physiology
Vertebrates: nervous system and sense organs
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Summary:Neuroimaging studies have identified frontal lobe brain abnormalities in migraineurs. Neuropsychological investigations highlighted frontal lobe related cognitive impairments in migraineurs, including working memory and executive function deficits. The relationship between brain anatomy and cognitive function in migraine, however, is unclear. The aim of this study was to simultaneously investigated cortex structure and executive function (EF) in patients with migraine and control subjects. Thus, we assessed grey matter (GM) density in 25 adult patients with migraine, compared to age and sex-matched control subjects, using magnetic resonance imaging (MRI) and voxel-based-morphometry (VBM), and we measured EF in the same population, employing three EF tasks of the Maudsley attention and response suppression (MARS) battery. Migraineurs, compared to control subjects, showed decreased frontal and parietal lobe GM density and slower response time to task set-shifting and, the delayed response time correlated significantly with reduced GM density of the frontal lobes in migraineurs. Frontal and parietal lobe abnormalities in migraineurs could be an underlying cause of significantly slower response time during cognitive set-shifting.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2008.05.033