Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who dev...

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Bibliographic Details
Published in:	American journal of clinical dermatology 2008-01, Vol.9 (4), p.267-270
Main Authors:	Gambichler, Thilo, Stücker, Markus, Kerner, Katja, Weiner, Stefan, Waldherr, Rüdiger, Altmeyer, Peter, Kreuter, Alexander
Format:	Article
Language:	eng
Subjects:	Acute renal failure Biological and medical sciences Care and treatment Case Report Case studies Dermatology Diagnosis Fatal Outcome Humans Kidney - pathology Kidneys Male Medical sciences Medicine Medicine & Public Health Melanins - urine Melanoma Melanoma - pathology Melanosis Melanosis - pathology Middle Aged Neoplasm Metastasis Nephrology. Urinary tract diseases Pharmacology/Toxicology Pharmacotherapy Pigmentary diseases of the skin Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions Urinary system involvement in other diseases. Miscellaneous
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Summary:	Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who developed acute kidney injury that was clinically indicated by an increase in urinary excreted metabolites in the serum. Histopathologic examination of kidney tissue revealed damage to tubules associated with disseminated intra-tubular melanin deposits. Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients.
ISSN:	1175-0561 1179-1888