Acute Inflammation of the Proliferative Zone of Gastric Mucosa in Helicobacter pylori Gastritis

The neutrophilic infiltration has been regarded to represent the activity of Helicobacter pylori gastritis. It may involve the epithelium and/or lamina propria. The incidence and degree of the two types of infiltration do not correlate with each other frequently. We correlated the two types of neutr...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 1999-01, Vol.195 (10), p.689-697
Main Authors: Yu, Eunsil, Lee, Hun Kyung, Kim, Hae Ryun, Lee, Moo-Song, Lee, Inchul
Format: Article
Language:English
Subjects:
Acute epithelial inflammation
Biopsy
Cell Division
Epithelium - pathology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastritis - epidemiology
Gastritis - microbiology
Gastritis - pathology
H. pylori gastritis
Helicobacter Infections - complications
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori - pathogenicity
Humans
Immunoenzyme Techniques
Incidence
Inflammation - microbiology
Inflammation - pathology
Neutrophils - pathology
Proliferative zone
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The neutrophilic infiltration has been regarded to represent the activity of Helicobacter pylori gastritis. It may involve the epithelium and/or lamina propria. The incidence and degree of the two types of infiltration do not correlate with each other frequently. We correlated the two types of neutrophilic infiltration with H. pylori infection and other pathologic parameters respectively in 300 randomly selected gastric biopsies as well as serial biopsies from a separate group of 95 patients who were treated for H. pylori infection. The ‘random biopsies’ had chronic gastritis of various degrees, and the organisms were identified in 239 cases (79.7%); in the ‘treated group,’ the organisms disappeared completely in 62 cases (65.3%). Characteristically, the intraepithelial neutrophilic infiltration was predominantly localized to the proliferative zone of the gastric mucosa (zone 2) where the density of H. pylori was considerably lower than the surface epithelium. In the ‘random biopsies,’ both acute epithelial and interstitial neutrophilic infiltration correlated significantly (p < 0.01) with the H. pylori infection. In the ‘treated group,’ however, only acute epithelial inflammation correlated significantly (p < 0.01) with the eradication of infection while acute interstitial inflammation did not. Acute epithelial inflammation was no less frequently present in advanced chronic gastritis than in early chronic gastritis. Acute epithelial inflammation of the proliferative zone is a characteristic pathologic finding of H. pylori gastritis, and appears to be directly associated with the pathogenesis of H. pylori gastritis and its progression.
ISSN:0344-0338
1618-0631
DOI:10.1016/S0344-0338(99)80060-0