ZAP70 in chronic lymphocytic leukaemia

The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein prov...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2008, Vol.40 (9), p.1654-1658
Main Authors: Amin, Shilu, Parker, Anton, Mann, Jelena
Format: Article
Language:English
Subjects:
Animals
Chronic lymphocytic leukaemia
Enzyme Activation
Epigenetics
Gene Expression Regulation, Neoplastic
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - enzymology
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Lymphocytes - metabolism
Lymphocytes - pathology
ZAP-70 Protein-Tyrosine Kinase - chemistry
ZAP-70 Protein-Tyrosine Kinase - genetics
ZAP-70 Protein-Tyrosine Kinase - metabolism
ZAP70
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Summary:The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein provides an ideal prognostic marker for the disease. A previous study has shown differential CpG methylation of a 5′ region of ZAP70 in leukaemic lymphoid cells, although no further epigenetic studies have been reported. Further investigation into the expression of ZAP70 may therefore provide targets for therapies.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2007.05.016