Visceral adipose tissue area is an independent risk factor for hepatic steatosis

Background and Aim:  Recent data indicate that hepatic steatosis is associated with insulin resistance, dyslipidemia and obesity (especially central body fat distribution). There have been few studies on the correlation between biopsy‐proven hepatic steatosis and the above factors in a disease‐free...

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Published in:Journal of gastroenterology and hepatology 2008-06, Vol.23 (6), p.900-907
Main Authors: Park, Bum J, Kim, Yoon J, Kim, Dong H, Kim, Won, Jung, Yong J, Yoon, Jung H, Kim, Chung Y, Cho, Young M, Kim, Se H, Lee, Kyoung B, Jang, Ja J, Lee, Hyo S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biopsy
Body Fat Distribution
Body Mass Index
Fatty Liver - diagnostic imaging
Fatty Liver - etiology
Fatty Liver - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intra-Abdominal Fat - diagnostic imaging
Intra-Abdominal Fat - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Living Donors
Male
Medical sciences
Metabolic diseases
metabolic syndrome
Middle Aged
Miscellaneous
non-alcoholic fatty liver disease
Obesity
Obesity - complications
Odds Ratio
Other diseases. Semiology
Other metabolic disorders
Regression Analysis
Retrospective Studies
Risk Factors
steatosis
Subcutaneous Fat - diagnostic imaging
Subcutaneous Fat - pathology
Tomography, X-Ray Computed
visceral adipose tissue
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Summary:Background and Aim:  Recent data indicate that hepatic steatosis is associated with insulin resistance, dyslipidemia and obesity (especially central body fat distribution). There have been few studies on the correlation between biopsy‐proven hepatic steatosis and the above factors in a disease‐free population. The aim of the present study was to evaluate the relation between hepatic steatosis assessed by biopsy and clinical characteristics including regional fat distribution measured by computed tomography (CT) in living liver donors. Methods:  Laboratory data, liver/spleen Hounsfield ratio (L/S ratio), regional fat distribution by CT and liver status by biopsy were evaluated retrospectively in a total of 177 living liver donors without a history of alcohol intake. Results:  The unpaired t‐test showed that age, triglycerides (TG), high density lipoprotein, total cholesterol, alanine aminotransferase, body mass index, L/S ratio, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) were associated with hepatic steatosis. In the multiple logistic regression analysis, VAT (odds ratio 1.031, 95% CI 1.013–1.048, P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2007.05212.x