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Texture analysis of spinal cord pathology in multiple sclerosis

Texture analysis was applied to MR images of the spinal cord in an attempt to quantify pathological changes that occur in multiple sclerosis (MS). Texture features quantify macroscopic lesions and also the microscopic abnormalities that may be undetectable using conventional measures of lesion volum...

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Published in:	Magnetic resonance in medicine 1999-11, Vol.42 (5), p.929-935
Main Authors:	Mathias, J.M., Tofts, P.S., Losseff, N.A.
Format:	Article
Language:	English
Subjects:	Adult Biological and medical sciences Female Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Middle Aged multiple sclerosis Multiple Sclerosis - diagnosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system Neurology Observer Variation Predictive Value of Tests Radiodiagnosis. Nmr imagery. Nmr spectrometry Reproducibility of Results Sensitivity and Specificity Spinal Cord - pathology spinal cord atrophy T2-weighted imaging texture analysis
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description	Texture analysis was applied to MR images of the spinal cord in an attempt to quantify pathological changes that occur in multiple sclerosis (MS). Texture features quantify macroscopic lesions and also the microscopic abnormalities that may be undetectable using conventional measures of lesion volume and number. Significant differences in texture between normal controls and MS patients were seen. Texture differences were detected between normal controls and relapsing–remitting patients before detectable spinal cord atrophy. There was also significant correlation between texture and disability. The segmentation and texture analysis technique demonstrates intraobserver coefficients of variation ranging from 0.6–8.2%. Texture analysis has potential as a tool for monitoring changes associated with the development of disability in patients with MS. Reproducibility and sensitivity must be improved to use the technique for serial monitoring in individuals. Magn Reson Med 42:929–935, 1999. © 1999 Wiley‐Liss, Inc.
doi_str_mv	10.1002/(SICI)1522-2594(199911)42:5<929::AID-MRM13>3.0.CO;2-2
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Reson. Med</addtitle><description>Texture analysis was applied to MR images of the spinal cord in an attempt to quantify pathological changes that occur in multiple sclerosis (MS). Texture features quantify macroscopic lesions and also the microscopic abnormalities that may be undetectable using conventional measures of lesion volume and number. Significant differences in texture between normal controls and MS patients were seen. Texture differences were detected between normal controls and relapsing–remitting patients before detectable spinal cord atrophy. There was also significant correlation between texture and disability. The segmentation and texture analysis technique demonstrates intraobserver coefficients of variation ranging from 0.6–8.2%. Texture analysis has potential as a tool for monitoring changes associated with the development of disability in patients with MS. Reproducibility and sensitivity must be improved to use the technique for serial monitoring in individuals. Magn Reson Med 42:929–935, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>multiple sclerosis</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Observer Variation</subject><subject>Predictive Value of Tests</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spinal Cord - pathology</subject><subject>spinal cord atrophy</subject><subject>T2-weighted imaging</subject><subject>texture analysis</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkF1v0zAYRi0EYmXwF1AuENouUl5_Ji5fmgKUom0VrIzLV07iQMBtQpyI9d_jkqoggcSVZev46NEh5DmFKQVgT06uFtnilErGYia1OKFaa0pPBZvJZ5rp2exs8Sq--HBB-Qs-hWm2fBrAW2Ry-HGbTCAREHOqxRG55_1XANA6EXfJEQUpGJdsQl6u7E0_dDYyG-O2vvZRU0W-rcMtKpqujFrTf2lc83kb1ZtoPbi-bp2NfOFs1wT8PrlTGeftg_15TD6-eb3K3sbny_kiOzuPCwkpj41SaVoVsmC0EimjXJUJGBAlSxjPBYDNpS7TgpWiystc8KpSKnSQuVIcdM6PyePR23bN98H6Hte1L6xzZmObwaPSjKVUpfwwoAj7fGcrbLt6bbotUsBdWcRdWdx1wl0nHMuiYCgxlEUMZfFXWeQImC0xgMH7cD9gyNe2_MM6pgzAoz1gfGFc1ZlNUfvfHE2BUwjY9Yj9qJ3d_jXuP9v-NW18COJ4FNe-tzcHsem-oUp4IvHT5Rzlu8v5-9X1FWr-E9u9rpo</recordid><startdate>199911</startdate><enddate>199911</enddate><creator>Mathias, J.M.</creator><creator>Tofts, P.S.</creator><creator>Losseff, N.A.</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199911</creationdate><title>Texture analysis of spinal cord pathology in multiple sclerosis</title><author>Mathias, J.M. ; Tofts, P.S. ; Losseff, N.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5083-a6688fc5c21f482136d70a04d2723b400eb59d8c2d4fbdb43ff661005b66309b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>multiple sclerosis</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple sclerosis and variants. 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subjects	Adult Biological and medical sciences Female Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Middle Aged multiple sclerosis Multiple Sclerosis - diagnosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system Neurology Observer Variation Predictive Value of Tests Radiodiagnosis. Nmr imagery. Nmr spectrometry Reproducibility of Results Sensitivity and Specificity Spinal Cord - pathology spinal cord atrophy T2-weighted imaging texture analysis
title	Texture analysis of spinal cord pathology in multiple sclerosis
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