Texture analysis of spinal cord pathology in multiple sclerosis

Texture analysis was applied to MR images of the spinal cord in an attempt to quantify pathological changes that occur in multiple sclerosis (MS). Texture features quantify macroscopic lesions and also the microscopic abnormalities that may be undetectable using conventional measures of lesion volum...

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Bibliographic Details
Published in:Magnetic resonance in medicine 1999-11, Vol.42 (5), p.929-935
Main Authors: Mathias, J.M., Tofts, P.S., Losseff, N.A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Humans
Image Processing, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system
Neurology
Observer Variation
Predictive Value of Tests
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reproducibility of Results
Sensitivity and Specificity
Spinal Cord - pathology
spinal cord atrophy
T2-weighted imaging
texture analysis
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Description
Summary:Texture analysis was applied to MR images of the spinal cord in an attempt to quantify pathological changes that occur in multiple sclerosis (MS). Texture features quantify macroscopic lesions and also the microscopic abnormalities that may be undetectable using conventional measures of lesion volume and number. Significant differences in texture between normal controls and MS patients were seen. Texture differences were detected between normal controls and relapsing–remitting patients before detectable spinal cord atrophy. There was also significant correlation between texture and disability. The segmentation and texture analysis technique demonstrates intraobserver coefficients of variation ranging from 0.6–8.2%. Texture analysis has potential as a tool for monitoring changes associated with the development of disability in patients with MS. Reproducibility and sensitivity must be improved to use the technique for serial monitoring in individuals. Magn Reson Med 42:929–935, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/(SICI)1522-2594(199911)42:5<929::AID-MRM13>3.0.CO;2-2