The effect of orally administered viable probiotic and dairy lactobacilli on mouse lymphocyte proliferation

Abstract Four common Lactobacillus strains were screened for their effects on proliferation of mouse splenic lymphocytes. Mice received perorally 109 viable bacteria kg−1 body weight for 7 days. Lactobacillus acidophilus treatment enhanced ex vivo basal proliferation (by 43%) and B-cell response at...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1999-11, Vol.26 (2), p.131-135
Main Authors: Kirjavainen, Pirkka V., El-Nezami, Hani S., Salminen, Seppo J., Ahokas, Jorma T., Wright, Paul F.A.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Administration, Oral
Animals
Biological and medical sciences
Biotechnology
Body weight
Cell Division
Concanavalin A
Concanavalin A - pharmacology
Cytotoxicity
Food industries
Food microbiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Health. Pharmaceutical industry
Immunobiology
Immunomodulation
Industrial applications and implications. Economical aspects
Lactobacilli
Lactobacillus
Lactobacillus acidophilus
Lactobacillus casei
Lactobacillus gasseri
Lactobacillus rhamnosus
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Lymphocyte proliferation
Lymphocytes
Lymphocytes - cytology
Lymphocytes B
Lymphocytes T
Male
Mice
Miscellaneous
Mitogen cytotoxicity
Mitogens
Mitogens - pharmacology
Modulation of the immune response (stimulation, suppression)
Oral administration
Probiotic bacterium
Probiotics
Probiotics - administration & dosage
Probiotics - pharmacology
Species Specificity
Spleen
Spleen - cytology
Strains (organisms)
Yogurt
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Summary:Abstract Four common Lactobacillus strains were screened for their effects on proliferation of mouse splenic lymphocytes. Mice received perorally 109 viable bacteria kg−1 body weight for 7 days. Lactobacillus acidophilus treatment enhanced ex vivo basal proliferation (by 43%) and B-cell response at suboptimal and optimal concentrations of lipopolysaccharide (LPS) (by 27–28%). Conversely, Lactobacillus casei, Lactobacillus gasseri and Lactobacillus rhamnosus inhibited both basal proliferation (by 14–51%) and mitogen-stimulated lymphoproliferation, particularly at supra-optimal concentrations of concanavalin A (by 43–68%) and LPS (by 23–62%). Therefore, these Lactobacillus strains demonstrate strain-specific effects on B- and T-cells and may also alter the splenocyte sensitivity to the cytotoxic effects of mitogens.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.1999.tb01380.x