New cycloalkylpyrazoles as potential cyclooxygenase inhibitors

In this study some cycloalkyl-3-( N-substituted carbamoyl)-1-phenylpyrazoles have been synthesized in order to screen their capability to inhibit human cyclooxygenase. The synthetic pathway is based on the well known property of nitrilimines to undergo 1,3-dipolar cycloaddition reactions. The struct...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 1998-10, Vol.53 (10), p.698-708
Main Authors: Cardia, M.C., Corda, L., Fadda, A.M., Maccioni, A.M., Maccioni, E., Plumitallo, A.
Format: Article
Language:English
Subjects:
Analgesic and antipyretic activity
Chemistry
Cycloalkyl-3-( N-substituted carbamoyl)-1-phenylpyrazoles
Cyclooxygenase Inhibitors - chemical synthesis
Cyclooxygenase Inhibitors - chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Humans
Magnetic Resonance Spectroscopy
Organic chemistry
Preparations and properties
Pyrazoles - chemical synthesis
Pyrazoles - chemistry
Stereoisomerism
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Summary:In this study some cycloalkyl-3-( N-substituted carbamoyl)-1-phenylpyrazoles have been synthesized in order to screen their capability to inhibit human cyclooxygenase. The synthetic pathway is based on the well known property of nitrilimines to undergo 1,3-dipolar cycloaddition reactions. The structures of all the synthesized compounds have been elucidated by means of both analytical and spectroscopic methods.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(98)00090-1