p53 and apoptosis

One of the several biological functions attributed to p53 is the ability to induce apoptotic cell suicide. It has become clear that this apoptotic activity of p53 is central to its role as a tumor suppressor. A summary of current knowledge concerning the mechanisms of p53-mediated apoptosis is prese...

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Bibliographic Details
Published in:Seminars in cancer biology 1998, Vol.8 (5), p.359-368
Main Authors: Gottlieb, Tanya M., Oren, Moshe
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Cell Cycle
Genes, p53
Humans
p53/tumor suppressor/apoptosis
Transcriptional Activation
Tumor Suppressor Protein p53 - physiology
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Summary:One of the several biological functions attributed to p53 is the ability to induce apoptotic cell suicide. It has become clear that this apoptotic activity of p53 is central to its role as a tumor suppressor. A summary of current knowledge concerning the mechanisms of p53-mediated apoptosis is presented. The pivotal `choice' between p53-induced viable growth arrest and apoptosis is discussed.
ISSN:1044-579X
1096-3650
DOI:10.1006/scbi.1998.0098