Negative and positive masking responses to light in retinal degenerate slow ( rds/ rds) mice during aging

Bright light suppresses locomotor activity in mice (negative masking) but dim light augments activity (positive masking). Retinal degeneration slow mice ( rds/ rds) were tested for responses to light at 3 months, 1 and 2 years old. The suppressive effect of light increased between 1 and 2 years, but...

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Bibliographic Details
Published in:Vision research (Oxford) 2008-05, Vol.48 (10), p.1270-1273
Main Authors: Mrosovsky, N., Thompson, Stewart
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Aging - psychology
Animals
Biological and medical sciences
Circadian Rhythm
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Locomotion
Male
Masking
Medical sciences
Mice
Mice, Inbred C3H
Mice, Mutant Strains
Motor Activity
Ophthalmology
Perceptual Masking
Photic Stimulation - methods
Psychomotor Performance
Retinal degeneration
Retinal Degeneration - physiopathology
Retinal Degeneration - psychology
Retinopathies
Vertebrates: nervous system and sense organs
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Summary:Bright light suppresses locomotor activity in mice (negative masking) but dim light augments activity (positive masking). Retinal degeneration slow mice ( rds/ rds) were tested for responses to light at 3 months, 1 and 2 years old. The suppressive effect of light increased between 1 and 2 years, but the positive response to dim lights was severely reduced at 1 year. No such effects occurred in aging wildtypes. The results indicate that enhancement of negative masking depends on the degree of degeneration of the classical photoreceptors, and that residual function in photoreceptors lacking outer segments is initially sufficient for positive masking.
ISSN:0042-6989
1878-5646
DOI:10.1016/j.visres.2008.02.016