BE-31405, a New Antifungal Antibiotic Produced by Penicillium minioluteum: I. Description of Producing Organism, Fermentation, Isolation, Physico-chemical and Biological Properties

A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent gr...

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Bibliographic Details
Published in:Journal of antibiotics 1998/12/25, Vol.51(12), pp.1081-1086
Main Authors: OKADA, HIROMASA, KAMIYA, SEIGO, SHIINA, YASUKO, SUWA, HIROAKI, NAGASHIMA, MASAO, NAKAJIMA, SHIGERU, SHIMOKAWA, HARUKI, SUGIYAMA, EIJI, KONDO, HISAO, KOJIRI, KATSUHISA, SUDA, HIROYUKI
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Antibiotics, Antineoplastic - pharmacology
Antifungal Agents - biosynthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Biotechnology
Bridged-Ring Compounds - chemistry
Bridged-Ring Compounds - metabolism
Bridged-Ring Compounds - pharmacology
Candida - drug effects
Candida albicans - drug effects
Chemical Phenomena
Chemistry, Physical
Cryptococcus neoformans
Cryptococcus neoformans - drug effects
Drug Screening Assays, Antitumor
Fermentation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
In Vitro Techniques
Indenes
Industrial applications and implications. Economical aspects
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Mice
Microbial Sensitivity Tests
Molecular Structure
Penicillium - metabolism
Penicillium minioluteum
Production of active biomolecules
Protein Synthesis Inhibitors - pharmacology
Rabbits
Reticulocytes - drug effects
Reticulocytes - metabolism
Tumor Cells, Cultured
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Description
Summary:A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.1081