Insulin-family peptide–receptor interaction at the early stage of vertebrate evolution

This is an overview of our studies on insulin and insulin-like growth factor-I (IGF-I) interactions with their own and each other’s receptors in the lamprey ( Lampetra fluviatilis L.), an extant representative of the ancient vertebrate group of Agnathans as compared to mammal (rat). Lamprey insulin...

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Bibliographic Details
Published in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 1998-09, Vol.121 (1), p.57-63
Main Authors: Leibush, B.N, Lappova, Y.L, Bondareva, V.M, Chistyacova, O.V, Gutiérrez, J, Plisetskaya, E.M
Format: Article
Language:English
Subjects:
Agnatha
Animals
Biological Evolution
Brackish
Brain - metabolism
Brain membranes
Downregulation
Endocytosis
Freshwater
Hepatocytes
Human IGF-1
Insulin - metabolism
Insulin-Like Growth Factor I - metabolism
Insulins: porcine, lamprey, salmonid, hagfish
Internalization
Lampetra fluviatilis
Lampreys
Liver - metabolism
Marine
Rats
Receptor
Receptor, IGF Type 1 - metabolism
Receptor, Insulin - metabolism
Species Specificity
Vertebrates
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Summary:This is an overview of our studies on insulin and insulin-like growth factor-I (IGF-I) interactions with their own and each other’s receptors in the lamprey ( Lampetra fluviatilis L.), an extant representative of the ancient vertebrate group of Agnathans as compared to mammal (rat). Lamprey insulin receptor shows species specificity, namely, it binds its own insulin with higher affinity than mammalian hormone. Nevertheless, and unlike mammalian insulin receptor, lamprey receptor discriminates relatively poorly between insulin and IGF-I. Autophosphorylation patterns are identical for both receptors. In contrast, IGF-I receptors in lamprey tissues are very similar to mammalin IGF-I receptors confirming known evolutionary conservatism of IGF receptor system. Presumed common evolutionary origin of insulin and IGF-I receptors and poor ability of lamprey insulin receptor to discriminate between two ligands, implies that lamprey insulin receptor is closer to putative ancestral protein than IGF-I receptor. Contrary to the common belief, ambient temperatures for lampreys (4–15°C) put no constraints on either downregulation of receptors or the endocytosis of hormone–receptor complexes.
ISSN:1096-4959
1879-1107
DOI:10.1016/S0305-0491(98)10109-8