New Biological Indicators to Evaluate and Monitor Radiation-Induced Damage: An Accident Case Report

Bertho, J. M., Roy, L., Souidi, M., Benderitter, M., Gueguen, Y., Lataillade, J. J., Prat, M., Fagot, T., De Revel, T. and Gourmelon, P. New Biological Indicators to Evaluate and Monitor Radiation-Induced Damage: An Accident Case Report. Radiat. Res. 169, 543–550 (2008). The aim of this work was to...

Full description

Saved in:
Bibliographic Details
Published in:Radiation research 2008-05, Vol.169 (5), p.543-550
Main Authors: Bertho, J. M., Roy, L., Souidi, M., Benderitter, M., Gueguen, Y., Lataillade, J. J., Prat, M., Fagot, T., De Revel, T., Gourmelon, P.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Blood
Blood Cell Count
Blood plasma
Cardiovascular system
Cardiovascular System - radiation effects
Cell Movement - radiation effects
Citrulline - blood
Cytokines
Diagnosis
Dosimetry
Follow-Up Studies
Gastrointestinal Tract - radiation effects
Hematopoiesis - radiation effects
Humans
Irradiation
Liver
Lymphocytes - cytology
Lymphocytes - radiation effects
Radiation accidents
Radiation damage
Radiation dosage
Radioactive Hazard Release
Radiometry
REGULAR ARTICLES
Space life sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bertho, J. M., Roy, L., Souidi, M., Benderitter, M., Gueguen, Y., Lataillade, J. J., Prat, M., Fagot, T., De Revel, T. and Gourmelon, P. New Biological Indicators to Evaluate and Monitor Radiation-Induced Damage: An Accident Case Report. Radiat. Res. 169, 543–550 (2008). The aim of this work was to use several new biological indicators to evaluate damage to the main physiological systems in a victim exposed accidentally to ionizing radiation. Blood samples were used for biological dosimetry and for measurement of the plasma concentrations of several molecules: Flt3 ligand to assess the hematopoietic system, citrulline as an indicator of the digestive tract, and several oxysterols as lipid metabolism and vascular markers. The cytogenetic evaluation estimated the dose to the victim to be between 4.2 and 4.8 Gy, depending on the methodology used. Monitoring the Flt3 ligand demonstrated the severity of bone marrow aplasia. In contrast, the citrulline concentration showed the absence of gastrointestinal damage. Variations in oxysterol concentrations suggested radiation-induced damage to the liver and the cardiovascular system. These results were correlated with those from classic biochemical markers, which demonstrated severe damage to the hematopoietic system and suggested the appearance of subclinical damage to the liver and cardiovascular system. These results demonstrate for the first time the importance of a multiparameter biological approach in the evaluation of radiation damage after accidental irradiation.
ISSN:0033-7587
1938-5404
DOI:10.1667/RR1259.1