Postoperative intrathecal patient‐controlled analgesia with bupivacaine, sufentanil or a mixture of both

In a randomised double‐blind study, 45 patients, scheduled for major orthopaedic surgery under continuous spinal anaesthesia, received for relief of postoperative pain patient‐controlled analgesia with either sufentanil 2 μgml−1, bupivacaine 0.0625% or a mixture of both by the intrathecal route. The...

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Bibliographic Details
Published in:Anaesthesia 1998-10, Vol.53 (10), p.1022-1027
Main Authors: Vercauteren, M. P., Geernaert, K., Hoffmann, V. L. H., Dohmen, D., Adriaensen, H. A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anaesthesia, techniques
regional, spinal
Analgesia, Patient-Controlled - methods
Analgesics, Opioid
Anesthesia
Anesthesia, Spinal - methods
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Local
Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Biological and medical sciences
Bupivacaine
Double-Blind Method
Drug Combinations
Female
Humans
Local anaesthetics
bupivacaine
Local anesthesia. Pain (treatment)
Male
Medical sciences
Opioids
sufentanil
Pain, Postoperative - drug therapy
Sufentanil
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Summary:In a randomised double‐blind study, 45 patients, scheduled for major orthopaedic surgery under continuous spinal anaesthesia, received for relief of postoperative pain patient‐controlled analgesia with either sufentanil 2 μgml−1, bupivacaine 0.0625% or a mixture of both by the intrathecal route. The mean (SD) consumption of sufentanil and bupivacaine during the first 12 h was 65.5 (27.1) μg and 18.2 (4.8) mg, respectively. Combining bupivacaine and sufentanil reduced the consumption of both to ≈40% as compared to the administration of each component separately. Pain relief was very good in all subjects, although this was obtained faster with the combined regimen. Moreover, more patients in this group remained completely painfree during the entire observation period (p 
ISSN:0003-2409
1365-2044
DOI:10.1046/j.1365-2044.1998.00517.x