Novel One-Pot Approach to Synthesis of Indanones through Sb(V)-Catalyzed Reaction of Phenylalkynes with Aldehydes

Catalytic SbF5 and the use of EtOH as an additive efficiently converted a mixture of phenylalkynes and aldehydes to indanone compounds in one pot, and the reaction stereoselectively afforded the corresponding 2,3-disubstituted indanones as a single trans-isomer.

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Bibliographic Details
Published in:Organic letters 2008-05, Vol.10 (9), p.1783-1785
Main Authors: Saito, Akio, Umakoshi, Masaharu, Yagyu, Naomi, Hanzawa, Yuji
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Alkynes - chemistry
Antimony - chemistry
Catalysis
Indans - chemical synthesis
Indans - chemistry
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Summary:Catalytic SbF5 and the use of EtOH as an additive efficiently converted a mixture of phenylalkynes and aldehydes to indanone compounds in one pot, and the reaction stereoselectively afforded the corresponding 2,3-disubstituted indanones as a single trans-isomer.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800539a