Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation

This study was designed to investigate whether small ubiquitin-like modifier (SUMO) conjugation is activated after focal cerebral ischemia. Transient ischemia induced a dramatic increase in SUMO2/3 protein conjugates. The most pronounced changes were found in the parietal cortex. SUMO2/3 conjugation...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2008-05, Vol.28 (5), p.892-896
Main Authors: Yang, Wei, Sheng, Huaxin, Warner, David S, Paschen, Wulf
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Western
Immunohistochemistry
Infarction, Middle Cerebral Artery - metabolism
Infarction, Middle Cerebral Artery - pathology
Ischemic Attack, Transient - metabolism
Ischemic Attack, Transient - pathology
Male
Medical sciences
Neurology
Neuropharmacology
Neuroprotective agent
Parietal Lobe - metabolism
Parietal Lobe - pathology
Pharmacology. Drug treatments
Rats
Rats, Wistar
Small Ubiquitin-Related Modifier Proteins - metabolism
SUMO-1 Protein - metabolism
Vascular diseases and vascular malformations of the nervous system
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Summary:This study was designed to investigate whether small ubiquitin-like modifier (SUMO) conjugation is activated after focal cerebral ischemia. Transient ischemia induced a dramatic increase in SUMO2/3 protein conjugates. The most pronounced changes were found in the parietal cortex. SUMO2/3 conjugation was particularly high in neurons located at the border of the middle cerebral artery territory where sumoylated proteins translocated to the nucleus. Considering the marked effect of SUMO conjugation on the function of target proteins, it is very likely that the postischemic activation of sumoylation has a significant effect on the fate of neurons exposed to transient ischemia.
ISSN:0271-678X
1559-7016
DOI:10.1038/sj.jcbfm.9600601