Segmental blood flow and rheological determinants in diabetic patients with peripheral occlusive arterial disease

Abstract Vascular abnormalities are more prevalent in the lower extremities in diabetic patients and may cause diminished perfusion to surrounding tissues. We sought to identify blood flow abnormalities in the leg of diabetic patients with peripheral occlusive arterial disease (POAD) and to determin...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2008-05, Vol.22 (3), p.210-216
Main Authors: Vigilance, Jacqueline Eleanor, Reid, Harvey L
Format: Article
Language:English
Subjects:
Adult
Aged
Arterial Occlusive Diseases - physiopathology
Blood flow
Blood Flow Velocity
Blood Viscosity
Diabetes mellitus
Diabetic Angiopathies - physiopathology
Endocrinology & Metabolism
Female
Fibrinogen
Fibrinogen - metabolism
Functional Laterality
Hematocrit
Humans
Leg - blood supply
Male
Middle Aged
Peripheral occlusive arterial disease
Viscosity
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Summary:Abstract Vascular abnormalities are more prevalent in the lower extremities in diabetic patients and may cause diminished perfusion to surrounding tissues. We sought to identify blood flow abnormalities in the leg of diabetic patients with peripheral occlusive arterial disease (POAD) and to determine whether these were associated with abnormalities in rheological determinants, namely, plasma fibrinogen concentration (PFC), relative plasma viscosity (RPV), hematocrit (Hct), and whole blood viscosity (WBV). Seventeen diabetic patients with POAD were compared with 40 diabetic patients without POAD and 19 nondiabetic control subjects. Blood flow was measured by venous occlusion plethysmography, RPV was measured by capillary viscometry, WBV was measured by a Wells–Brooksfield viscometer [at high (230 s−1 ) and low (23 s−1 ) shear rates], and PFC was measured by the clot–weight method of Ingram [Ingram, G. I. C. (1961). A suggested schedule for the rapid investigation of acute haemostatic failure. Journal of Clinical Pathology, 14 , 356–360]. Ankle blood flow ( Qak ) was significantly lower in diabetic patients with POAD than in diabetic patients without POAD ( P
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2006.11.001