The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

[2.2]Paracyclophane is a fascinating molecule that offers great potential in a wide range of chemical disciplines. Currently, the synthesis of the majority of enantiomerically pure [2.2]paracyclophane derivatives is based on the resolution of a small number of starting materials or individual resolu...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2008-01, Vol.6 (9), p.1527-1534
Main Author: Rowlands, Gareth J
Format: Article
Language:English
Subjects:
Cyclization
Halogenation
Molecular Conformation
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
Stereoisomerism
Sulfoxides - chemistry
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Summary:[2.2]Paracyclophane is a fascinating molecule that offers great potential in a wide range of chemical disciplines. Currently, the synthesis of the majority of enantiomerically pure [2.2]paracyclophane derivatives is based on the resolution of a small number of starting materials or individual resolution procedures are developed for each new compound. The development of more general routes to these valuable compounds via the resolution of a common intermediate is discussed. Ultimately, it would be preferable to synthesise these valuable compounds without recourse to resolution and ideas for this rewarding goal are postulated.
ISSN:1477-0520
1477-0539
DOI:10.1039/b800698a