Artesunate as a Potent Antiviral Agent in a Patient with Late Drug-Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation

This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7–2.1-log reduction in viral load by trea...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-05, Vol.46 (9), p.1455-1457
Main Authors: Shapira, Michael Y., Resnick, Igor B., Chou, Sunwen, Neumann, Avidan U., Lurain, Nell S., Stamminger, Thomas, Caplan, Orit, Saleh, Niveen, Efferth, Thomas, Marschall, Manfred, Wolf, Dana G.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Antiviral drugs
Antivirals
Artemisinins - pharmacology
Artemisinins - therapeutic use
Biological and medical sciences
Bone marrow, stem cells transplantation. Graft versus host reaction
Brief Reports
Child
Cytomegalovirus
Cytomegalovirus - drug effects
Cytomegalovirus infections
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - etiology
Disease prevention
DNA polymerase
Dosage
Drug resistance
Drug Resistance, Viral
Foscarnet - pharmacology
Foscarnet - therapeutic use
Genetic mutation
Hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - methods
Humans
Infections
Infectious diseases
Male
Medical sciences
Mutation
Pharmacology. Drug treatments
Research universities
Stem cells
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Treatment Outcome
Viral diseases
Viral load
Viruses
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Summary:This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7–2.1-log reduction in viral load by treatment day 7, with a viral half-life of 0.9–1.9 days, indicating a highly effective block in viral replication.
ISSN:1058-4838
1537-6591
DOI:10.1086/587106