Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma

The aim of this study was to investigate the prognostic value of cell proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow-up were analyzed. MIB-1 ant...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 1998-12, Vol.5 (8), p.699-705
Main Authors: Rijken, A M, Umezawa, A, van Gulik, T M, Bosma, A, Polak, M M, Offerhaus, G J, Obertop, H, Gouma, D J
Format: Article
Language:English
Subjects:
2-Methylisoborneol
Adult
Aged
Antigens
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Bile ducts
Carcinoma
Cell growth
Cell proliferation
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Deoxyribonucleic acid
Diploids
DNA
DNA, Neoplasm - analysis
Female
Flow Cytometry
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Male
Middle Aged
Ploidy
Prognosis
Survival Analysis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to investigate the prognostic value of cell proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow-up were analyzed. MIB-1 antibody was used for Ki-67 antigen detection to determine the proportion of proliferating cells. DNA content was measured using flow cytometry. A significant correlation was found between a low MIB-1 index (
ISSN:1068-9265
1534-4681
DOI:10.1007/bf02303480