Quantitative evaluation of 28 mineral elements by inductively coupled plasma/mass spectrometry and its application in source identification of Indian Opium

An analytical method based on inductively coupled plasma/mass spectrometry (ICP/MS) was developed for the determination of 28 mineral elements (Cr, Mn, Co, Ni, Cu, Zn, Ga, Sr, Cd, Ag, Ba, Pb, Bi Y, La, Ce, Nd, Pr, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu) in Indian opium samples. The detection lim...

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Bibliographic Details
Published in:Journal of AOAC International 2005-09, Vol.88 (5), p.1469-1484
Main Authors: Mudiam, M.R, Kumar, S.A, Mahadevan, S, Ghosh, P, Sarin, R.K, Beedu, S.R
Format: Article
Language:English
Subjects:
chemical constituents of plants
Composition
Drug Contamination
Identification and classification
India
Mass spectrometry
Mass Spectrometry - methods
Measurement
Metals, Rare Earth - analysis
Methods
mineral content
Opium
Opium - analysis
Opium - classification
Papaver somniferum subsp. setigerum
plant extracts
quantitative analysis
Sensitivity and Specificity
Trace Elements - analysis
Trace elements in nutrition
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Summary:An analytical method based on inductively coupled plasma/mass spectrometry (ICP/MS) was developed for the determination of 28 mineral elements (Cr, Mn, Co, Ni, Cu, Zn, Ga, Sr, Cd, Ag, Ba, Pb, Bi Y, La, Ce, Nd, Pr, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu) in Indian opium samples. The detection limits were found to be in the range of 0.0008-0.45 ng/mL. The recoveries of spiked samples for each element were found to be in the range of 83-106%, with a precision of less than 9%. A total of 124 opium samples from India were analyzed for the distribution pattern of the 28 mineral elements. Quantitative elemental data were subjected to chemometric analysis in order to determine an optimal classifier to evaluate the source of Indian opium. The study indicated that mineral elements might not be the suitable discriminators for the discrimination of licit opium-growing divisions of India. However, the methodology developed and the analytical data on elemental profile may find important forensic application in discriminating Indian opium with that of licit and illicit opium originating from different geographical regions of world.
ISSN:1060-3271
1944-7922
DOI:10.1093/jaoac/88.5.1469