Epithelioid hemangioendothelioma of the oral cavity

Objective:  To investigate the clinicopathological characteristics and biologic behaviour of epithelioid hemangioendothelioma in the oral cavity. Materials and methods:  The clinical features and pathological findings of nine cases with intraoral epithelioid hemangioendothelioma were reviewed, inclu...

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Bibliographic Details
Published in:Oral diseases 2007-03, Vol.13 (2), p.244-250
Main Authors: Sun, ZJ, Zhang, L, Zhang, WF, Chen, XM, Lai, FMM, Zhao, YF
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens, CD34 - analysis
Child
Dentistry
epithelioid hemangioendothelioma
Female
Gingival Neoplasms - pathology
Hemangioendothelioma, Epithelioid - pathology
Herpesvirus 8, Human - isolation & purification
Human herpesvirus
Humans
immunohistochemistry
Keratins - analysis
Lip Neoplasms - pathology
Male
Mandibular Neoplasms - pathology
Maxillary Neoplasms - pathology
Middle Aged
Mouth Floor - pathology
Mouth Mucosa - pathology
Mouth Neoplasms - pathology
Mucin-1 - analysis
Neoplasm Recurrence, Local - pathology
oral cavity
pathology
Retrospective Studies
S100 Proteins - analysis
Tongue Neoplasms - pathology
vascular tumour
Vimentin - analysis
von Willebrand Factor - analysis
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Summary:Objective:  To investigate the clinicopathological characteristics and biologic behaviour of epithelioid hemangioendothelioma in the oral cavity. Materials and methods:  The clinical features and pathological findings of nine cases with intraoral epithelioid hemangioendothelioma were reviewed, including immunohistochemistry study. Results:  This series comprised seven males and two females aged 6–53 years (mean 28 years). The sites of the tumour included the tongue (n = 4), lip (n = 1), the gingiva and alveoli of the maxilla (n = 1), the gingiva and alveoli of the mandible (n = 1), buccal mucosa (n = 1), and the floor of the mouth (n = 1). A painless solitary mass was the most common presentation and was found in eight cases. On pathology, the tumour grew in short strands, cords or nests of polygonal to slightly spindled epithelioid cells in fibro‐myxoid stroma, with formation of intracytoplasmic lumina. Tumour cells were immunoreactive to CD34, FVIIIRAg, and vimentin. Focal‐positive cytokeration were observed in three cases. Immunoreactivity for S‐100 protein, epithelial membrane antigen (EMA) and human herpesvirus (HHV)‐8 was negative in all cases. Two cases recurred after surgical excision, but no patient developed local or distant metastasis. Conclusions:  Wide local excision with long‐term follow‐up seems to be the treatment of choice for intraoral epithelioid hemangioendothelioma because of their unpredictable biological behaviour and recurrence potential.
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2006.01281.x