Helicobacter pylori, Ethnicity, and the Gastroesophageal Reflux Disease Spectrum: A Study from the East

Background:  Ethnic differences in gastroesophageal reflux disease (GERD) and its complications as well as racial variations in the prevalence of Helicobacter pylori infection are well documented. Nevertheless, the association between reflux disease, H. pylori, and race has not been adequately explo...

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Bibliographic Details
Published in:Helicobacter (Cambridge, Mass.) Mass.), 2007-04, Vol.12 (2), p.177-183
Main Authors: Rajendra, Shanmugarajah, Ackroyd, Roger, Robertson, Iain K., Ho, Jacqueline J., Karim, Norain, Kutty, Kannan M.
Format: Article
Language:English
Subjects:
Adult
Antigens, Bacterial - genetics
Asian
Bacterial Proteins - genetics
Barrett Esophagus - epidemiology
Barrett Esophagus - microbiology
Barrett's esophagus
cagA
Case-Control Studies
corpus atrophy
ethnicity
Female
gastritis
Gastroesophageal Reflux - epidemiology
Gastroesophageal Reflux - ethnology
Gastroesophageal Reflux - pathology
gastroesophageal reflux disease
Helicobacter Infections - epidemiology
Helicobacter Infections - ethnology
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - pathogenicity
Humans
Malaysia - epidemiology
Malaysia - ethnology
Male
Middle Aged
Prevalence
Prospective Studies
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Summary:Background:  Ethnic differences in gastroesophageal reflux disease (GERD) and its complications as well as racial variations in the prevalence of Helicobacter pylori infection are well documented. Nevertheless, the association between reflux disease, H. pylori, and race has not been adequately explored. Aims:  We estimated the strength of the association between H. pylori, ethnicity, and the gastroesophageal reflux disease (GERD) spectrum, including Barrett's esophagus, in Asian patients presenting for endoscopy in a tertiary referral center. Methods:  Prospectively, we studied 188 consecutive patients with GERD, short‐ and long‐segment Barrett's esophagus, and controls. All patients underwent gastroscopy with gastric biopsies to assess H. pylori, gastritis, and atrophy. CagA status and H. pylori infection were determined by immunoblot assay. Results:  The overall prevalence of H. pylori infection was 52.1% (of which 77.6% were cagA+) and was lowest in the long‐segment Barrett's esophagus group (36.7%) (p = .048). When Barrett's esophagus was present, the length of abnormality was 44.8% shorter in the presence of H. pylori (p = .015). Indians had the highest prevalence of H. pylori (75%) and Malays the lowest (19.6%) (p 
ISSN:1083-4389
1523-5378
DOI:10.1111/j.1523-5378.2007.00489.x