Effects of repeated praziquantel treatment on schistosomiasis mekongi morbidity as detected by ultrasonography

Schistosomiasis mekongi is endemic in the Mekong River basin; about 80,000 people are at risk of infection in Cambodia. We conducted ultrasonographic studies of patients with schistosomiasis mekongi in Kratie province, Cambodia, focusing especially on the relationship between the frequency of praziq...

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Bibliographic Details
Published in:Parasitology international 2006-12, Vol.55 (4), p.261-265
Main Authors: Chigusa, Yuichi, Ohmae, Hiroshi, Otake, Hidehiro, Keang, Hong, Sinuon, Muth, Saem, Cheam, Socheat, Duong, Matsuda, Hajime
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
Cambodia
Cambodia - epidemiology
Child
Female
Humans
Male
Middle Aged
Morbidity
Periportal fibrosis
Portal Vein - diagnostic imaging
Praziquantel
Praziquantel - pharmacology
Praziquantel - therapeutic use
Schistosoma - drug effects
Schistosoma - pathogenicity
Schistosoma mekongi
Schistosomiasis - diagnostic imaging
Schistosomiasis - drug therapy
Schistosomiasis - epidemiology
Splenic Vein - diagnostic imaging
Splenomegaly
Splenomegaly - diagnostic imaging
Splenomegaly - etiology
Ultrasonography
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Summary:Schistosomiasis mekongi is endemic in the Mekong River basin; about 80,000 people are at risk of infection in Cambodia. We conducted ultrasonographic studies of patients with schistosomiasis mekongi in Kratie province, Cambodia, focusing especially on the relationship between the frequency of praziquantel treatment and findings of ultrasonographic imaging. The frequency of praziquantel treatment in the period from 1995 to 2002 was classified into four groups: 1–2, 3–4, 5–6, and 7–8 times. Ultrasonographic images were examined to determine the presence of thickening of the portal vein wall and formation of meandering collateral circulation of the splenic vein. We selected these parameters because they are unaffected by interobserver bias. The results showed that thickening of the portal vein wall may have potential to improve with frequent praziquantel treatment. On the other hand, established hard splenomegaly and meandering collateral circulation of the splenic vein, improved very little with praziquantel treatment.
ISSN:1383-5769
1873-0329
DOI:10.1016/j.parint.2006.06.005