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Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population
Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population Marco R. Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subject...
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| Published in: | Journal of the American College of Cardiology 2007-02, Vol.49 (7), p.797-802 |
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| container_end_page | 802 |
| container_issue | 7 |
| container_start_page | 797 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 49 |
| creator | Di Tullio, Marco R., MD Sacco, Ralph L., MD Sciacca, Robert R., EngScD Jin, Zhezhen, PhD Homma, Shunichi, MD, FACC |
| description | Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population Marco R. Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subjects. Transthoracic echocardiography with contrast injection was used for the detection of PRO. During a mean follow-up of 79.7 ± 28.0 months, PFO was not found to be significantly associated with ischemic stroke after adjustment for demographics and other stroke risk factors (hazard ratio 1.64, 95% confidence interval 0.87 to 3.09). The coexistence of PFO with atrial septal aneurysm did not increase the stroke risk. Therefore, the PFO-related stroke risk in the general population appears low. Subgroups of subjects at increased risk may exist. |
| doi_str_mv | 10.1016/j.jacc.2006.08.063 |
| format | article |
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Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subjects. Transthoracic echocardiography with contrast injection was used for the detection of PRO. During a mean follow-up of 79.7 ± 28.0 months, PFO was not found to be significantly associated with ischemic stroke after adjustment for demographics and other stroke risk factors (hazard ratio 1.64, 95% confidence interval 0.87 to 3.09). The coexistence of PFO with atrial septal aneurysm did not increase the stroke risk. Therefore, the PFO-related stroke risk in the general population appears low. Subgroups of subjects at increased risk may exist.</description><identifier>ISSN: 0735-1097</identifier><identifier>ISSN: 1558-3597</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2006.08.063</identifier><identifier>PMID: 17306710</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>African Continental Ancestry Group - statistics & numerical data ; Age ; Age Factors ; Aged ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cohort Studies ; Comorbidity ; Confidence intervals ; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava ; Diabetes ; Ethnicity ; European Continental Ancestry Group - statistics & numerical data ; Female ; Gender ; Heart ; Heart Septal Defects, Atrial - ethnology ; Hispanic Americans - statistics & numerical data ; Hispanic people ; Humans ; Hypertension ; Incidence ; Internal Medicine ; Male ; Medical sciences ; Neurology ; New York City - epidemiology ; Older people ; Pneumology ; Population ; Prevalence ; Prospective Studies ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. 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Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subjects. Transthoracic echocardiography with contrast injection was used for the detection of PRO. During a mean follow-up of 79.7 ± 28.0 months, PFO was not found to be significantly associated with ischemic stroke after adjustment for demographics and other stroke risk factors (hazard ratio 1.64, 95% confidence interval 0.87 to 3.09). The coexistence of PFO with atrial septal aneurysm did not increase the stroke risk. Therefore, the PFO-related stroke risk in the general population appears low. Subgroups of subjects at increased risk may exist.</description><subject>African Continental Ancestry Group - statistics & numerical data</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</subject><subject>Diabetes</subject><subject>Ethnicity</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Gender</subject><subject>Heart</subject><subject>Heart Septal Defects, Atrial - ethnology</subject><subject>Hispanic Americans - statistics & numerical data</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>New York City - epidemiology</subject><subject>Older people</subject><subject>Pneumology</subject><subject>Population</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Stroke</subject><subject>Stroke - ethnology</subject><subject>Studies</subject><subject>Substance abuse treatment</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0735-1097</issn><issn>1558-3597</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kk2LFDEQhhtR3HH1D3iQgOitx0oy-QIRZHF1YWUHV88hna5m0tMfY9K9sP_eNDMwsAdPBeF5i6onVRRvKawpUPmpXbfO-zUDkGvQa5D8WbGiQuiSC6OeFytQXJQUjLooXqXUQgY1NS-LC6o4SEVhVWy3bsJhItdjdD0O5O7BdUjcUJNph-RXSHsyNuQm-R32wZP7KY57JGEgjvycuyngtBvy-3Y8zJ2bwji8Ll40rkv45lQviz_X335f_Shv777fXH29Lb2Qaio3ChlTUFW0Rl47pzlnjBlHjZYaHfqaK-OFYFL6RlSg6o1n4Ctlag4bFPyy-Hjse4jj3xnTZPuQPHadG3Cck5UGqDZcZ_D9E7Ad5zjk2SwVIKkWAkym2JHycUwpYmMPMfQuPloKdrFtW7vYtottC9pm2zn07tR6rnqsz5GT3gx8OAEuedc10Q0-pDOnxUZxyjL3-chhNvYQMNrkAw4e6xDRT7Yew__n-PIk7ruQv8V1e3zEdN7XJmbB3i93sZwFSGDGCOD_ACsIsEE</recordid><startdate>20070220</startdate><enddate>20070220</enddate><creator>Di Tullio, Marco R., MD</creator><creator>Sacco, Ralph L., MD</creator><creator>Sciacca, Robert R., EngScD</creator><creator>Jin, Zhezhen, PhD</creator><creator>Homma, Shunichi, MD, FACC</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20070220</creationdate><title>Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population</title><author>Di Tullio, Marco R., MD ; Sacco, Ralph L., MD ; Sciacca, Robert R., EngScD ; Jin, Zhezhen, PhD ; Homma, Shunichi, MD, FACC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-47e2270bb1de3daa8332229a19868eaecd379c55266cf5b07d4c20cb79d304e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>African Continental Ancestry Group - statistics & numerical data</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</topic><topic>Diabetes</topic><topic>Ethnicity</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Gender</topic><topic>Heart</topic><topic>Heart Septal Defects, Atrial - ethnology</topic><topic>Hispanic Americans - statistics & numerical data</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>New York City - epidemiology</topic><topic>Older people</topic><topic>Pneumology</topic><topic>Population</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Stroke</topic><topic>Stroke - ethnology</topic><topic>Studies</topic><topic>Substance abuse treatment</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Tullio, Marco R., MD</creatorcontrib><creatorcontrib>Sacco, Ralph L., MD</creatorcontrib><creatorcontrib>Sciacca, Robert R., EngScD</creatorcontrib><creatorcontrib>Jin, Zhezhen, PhD</creatorcontrib><creatorcontrib>Homma, Shunichi, MD, FACC</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Tullio, Marco R., MD</au><au>Sacco, Ralph L., MD</au><au>Sciacca, Robert R., EngScD</au><au>Jin, Zhezhen, PhD</au><au>Homma, Shunichi, MD, FACC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2007-02-20</date><risdate>2007</risdate><volume>49</volume><issue>7</issue><spage>797</spage><epage>802</epage><pages>797-802</pages><issn>0735-1097</issn><issn>1558-3597</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population Marco R. Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subjects. Transthoracic echocardiography with contrast injection was used for the detection of PRO. During a mean follow-up of 79.7 ± 28.0 months, PFO was not found to be significantly associated with ischemic stroke after adjustment for demographics and other stroke risk factors (hazard ratio 1.64, 95% confidence interval 0.87 to 3.09). The coexistence of PFO with atrial septal aneurysm did not increase the stroke risk. Therefore, the PFO-related stroke risk in the general population appears low. Subgroups of subjects at increased risk may exist.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17306710</pmid><doi>10.1016/j.jacc.2006.08.063</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | African Continental Ancestry Group - statistics & numerical data Age Age Factors Aged Biological and medical sciences Cardiac arrhythmia Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cohort Studies Comorbidity Confidence intervals Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava Diabetes Ethnicity European Continental Ancestry Group - statistics & numerical data Female Gender Heart Heart Septal Defects, Atrial - ethnology Hispanic Americans - statistics & numerical data Hispanic people Humans Hypertension Incidence Internal Medicine Male Medical sciences Neurology New York City - epidemiology Older people Pneumology Population Prevalence Prospective Studies Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory system : syndromes and miscellaneous diseases Risk Factors Sex Distribution Sex Factors Stroke Stroke - ethnology Studies Substance abuse treatment Vascular diseases and vascular malformations of the nervous system |
| title | Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population |
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