Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population

Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population Marco R. Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subject...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-02, Vol.49 (7), p.797-802
Main Authors: Di Tullio, Marco R., MD, Sacco, Ralph L., MD, Sciacca, Robert R., EngScD, Jin, Zhezhen, PhD, Homma, Shunichi, MD, FACC
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - statistics & numerical data
Age
Age Factors
Aged
Biological and medical sciences
Cardiac arrhythmia
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cohort Studies
Comorbidity
Confidence intervals
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Diabetes
Ethnicity
European Continental Ancestry Group - statistics & numerical data
Female
Gender
Heart
Heart Septal Defects, Atrial - ethnology
Hispanic Americans - statistics & numerical data
Hispanic people
Humans
Hypertension
Incidence
Internal Medicine
Male
Medical sciences
Neurology
New York City - epidemiology
Older people
Pneumology
Population
Prevalence
Prospective Studies
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Respiratory system : syndromes and miscellaneous diseases
Risk Factors
Sex Distribution
Sex Factors
Stroke
Stroke - ethnology
Studies
Substance abuse treatment
Vascular diseases and vascular malformations of the nervous system
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Summary:Patent Foramen Ovale and the Risk of Ischemic Stroke in a Multiethnic Population Marco R. Di Tullio, Ralph L. Sacco, Robert R. Sciacca, Zhezhen Jin, Shunichi Homma The ischemic stroke risk associated with a patent foramen ovale (PFO) was evaluated in a multiethnic cohort of 1,100 stroke-free subjects. Transthoracic echocardiography with contrast injection was used for the detection of PRO. During a mean follow-up of 79.7 ± 28.0 months, PFO was not found to be significantly associated with ischemic stroke after adjustment for demographics and other stroke risk factors (hazard ratio 1.64, 95% confidence interval 0.87 to 3.09). The coexistence of PFO with atrial septal aneurysm did not increase the stroke risk. Therefore, the PFO-related stroke risk in the general population appears low. Subgroups of subjects at increased risk may exist.
ISSN:0735-1097
1558-3597
1558-3597
DOI:10.1016/j.jacc.2006.08.063