Beneficial effects of 1-year optimal medical treatment with and without additional PTA on inflammatory markers of atherosclerosis in patients with PAD. Results from the Oslo Balloon Angioplasty versus Conservative Treatment (OBACT) study

The influence of optimal medical treatment (OMT) with or without additional percutaneous transluminal angioplasty (PTA) on vascular inflammation in peripheral arterial occlusive disease (PAD) patients was investigated. Patients with intermittent claudication (IC) and angiographically verified PAD we...

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Bibliographic Details
Published in:Vascular medicine (London, England) England), 2007-11, Vol.12 (4), p.275-283
Main Authors: Nylænde, M., Kroese, A.J., Morken, B., Stranden, E., Sandbæk, G., Lindahl, A.K., Arnesen, H., Seljeflot, I.
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon
Ankle - blood supply
Atherosclerosis - blood
Atherosclerosis - complications
Atherosclerosis - drug therapy
Atherosclerosis - physiopathology
Atherosclerosis - therapy
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Blood Pressure
Brachial Artery - physiopathology
Cardiology. Vascular system
Cardiovascular Agents - therapeutic use
Cardiovascular system
Combined Modality Therapy
Diseases of the cardiovascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Finland
Humans
Inflammation - blood
Inflammation - complications
Inflammation - drug therapy
Inflammation - physiopathology
Inflammation - therapy
Intermittent Claudication - blood
Intermittent Claudication - drug therapy
Intermittent Claudication - etiology
Intermittent Claudication - physiopathology
Intermittent Claudication - therapy
Male
Medical sciences
Middle Aged
Pain Measurement
Peripheral Vascular Diseases - blood
Peripheral Vascular Diseases - complications
Peripheral Vascular Diseases - drug therapy
Peripheral Vascular Diseases - physiopathology
Peripheral Vascular Diseases - therapy
Pharmacology. Drug treatments
Prospective Studies
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recovery of Function
Severity of Illness Index
Time Factors
Treatment Outcome
Vasodilator agents. Cerebral vasodilators
Walking
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Summary:The influence of optimal medical treatment (OMT) with or without additional percutaneous transluminal angioplasty (PTA) on vascular inflammation in peripheral arterial occlusive disease (PAD) patients was investigated. Patients with intermittent claudication (IC) and angiographically verified PAD were randomized to OMT (n = 28) or OMT + PTA (n = 28) and followed for 12 months. Ankle—brachial index (ABI), treadmill walking distances (WD), visual analogue scale (VAS), and blood sampling for the determination of selected soluble biomarkers were undertaken at baseline and after 3 and 12 months. After both 3 and 12 months, ABI, WD and VAS were highly significantly improved in favour of OMT + PTA (p < 0.05 for all). Significant improvements were recorded in both groups in serum lipids (p < 0.01 for all), except for triglycerides, and in the inflammatory markers P-selectin, interleukin-6, interleukin-10, monocyte chemoattractant protein-1 and fibrinogen (p < 0.05 for all). There were, however, no differences in the changes from baseline between the groups in any variable. Intervention with OMT alone or in combination with PTA did not differ with regard to the effects on serum lipids and markers of inflammation in our population of PAD patients. The combined treatment was, however, better for the treadmill walking distance.
ISSN:1358-863X
1477-0377
DOI:10.1177/1358863X07082720