Optical Recording of Action Potentials and Other Discrete Physiological Events: A Perspective from Signal Detection Theory

Lucas Sjulson and Gero Miesenböck Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut lukesjulson{at}gmail.com Optical imaging of physiological events in real time can yield insights into biological function that would be difficult to obtain by other experimental m...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2007-02, Vol.22 (1), p.47-55
Main Authors: Sjulson, Lucas, Miesenbock, Gero
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Microscopy, Confocal - methods
Models, Theoretical
Neurons - physiology
Optics and Photonics
Photons
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Summary:Lucas Sjulson and Gero Miesenböck Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut lukesjulson{at}gmail.com Optical imaging of physiological events in real time can yield insights into biological function that would be difficult to obtain by other experimental means. However, the detection of all-or-none events, such as action potentials or vesicle fusion events, in noisy single-trial data often requires a careful balance of tradeoffs. The analysis of such experiments, as well as the design of optical reporters and instrumentation for them, is aided by an understanding of the principles of signal detection. This review illustrates these principles, using as an example action potential recording with optical voltage reporters.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00036.2006