Water soluble complexes of chitosan-g-MPEG and hyaluronic acid

Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS‐g‐MPEG) and negatively charged hyaluronic acid (HA). CS‐g‐MPEGs having different degrees of substituti...

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Published in:Journal of biomedical materials research. Part A 2007-03, Vol.80A (4), p.800-812
Main Authors: Wu, Jun, Wang, Xuefen, Keum, Jong Kahk, Zhou, Hongwen, Gelfer, Mikhail, Avila-Orta, Carlos-Alberto, Pan, Hui, Chen, Weiliam, Chiao, Shu-Min, Hsiao, Benjamin S., Chu, Benjamin
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Chitosan - chemistry
chitosan-g-MPEG
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
hyaluronic acid
Hyaluronic Acid - chemistry
Molecular Structure
Molecular Weight
polyelectrolyte complex
Polyethylene Glycols - chemistry
rheology
SAXS
Solubility
Temperature
Viscosity
Water - chemistry
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Summary:Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS‐g‐MPEG) and negatively charged hyaluronic acid (HA). CS‐g‐MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG‐aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS‐g‐MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS‐g‐MPEG solution. The highest viscosity was obtained when the charge ratio of CS‐g‐MPEG/HA was close to 1.0. Small‐angle X‐ray scattering measurements provided some insights into the lamellar structure of the CS‐g‐MPEG/HA complex. The CS‐g‐MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium). © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.30972