Comment on the use of self‐reporting instruments to assess patients with rheumatoid arthritis: The longitudinal association between the DAS28 and the VAS general health

Objective Recently, the use of patient self‐reporting instruments instead of clinical, objective measurements to assess rheumatoid arthritis (RA) patients was proposed. This assumes a constant association between disease activity and the self‐reporting instruments. The objective was to explore the a...

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Bibliographic Details
Published in:Arthritis and rheumatism 2006-10, Vol.55 (5), p.745-750
Main Authors: Kievit, W., Welsing, P. M. J., Adang, E. M. M., Eijsbouts, A. M., Krabbe, P. F. M., van Riel, P. L. C. M.
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - physiopathology
Arthritis, Rheumatoid - psychology
Biological and medical sciences
Cross-Sectional Studies
Disability Evaluation
Disease activity score
Disease Progression
Diseases of the osteoarticular system
Female
Follow-Up Studies
Health Status
Humans
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Outcome Assessment (Health Care) - methods
Outcome assessments
Pain Measurement - methods
Regression Analysis
Response shift
Rheumatoid arthritis
Self Concept
Severity of Illness Index
Surveys and Questionnaires
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Summary:Objective Recently, the use of patient self‐reporting instruments instead of clinical, objective measurements to assess rheumatoid arthritis (RA) patients was proposed. This assumes a constant association between disease activity and the self‐reporting instruments. The objective was to explore the association (in time) between disease activity and patient perception of general health, disease activity, pain, and functional disability in patients with RA. Methods Data of 624 newly diagnosed RA patients who completed 3 years of followup were analyzed. Cross‐sectional linear regression models and longitudinal regression models were estimated, with a visual analog scale (VAS) measuring general health (VAS‐GH; 0 = best, 100 = worst) as a dependent variable and the Disease Activity Score (DAS28) without the VAS‐GH as an independent variable. Other dependent variables were VAS disease activity, pain, and the Health Assessment Questionnaire. Results The DAS28 and VAS‐GH were significantly associated in RA patients (P < 0.001). However, the explained variance was low (6.7%). From diagnosis to 3 years after the diagnosis, the intercept decreased given the same regression coefficient. The longitudinal regression model showed that the VAS‐GH improved during disease course independent of a change in DAS28. Analyses on the other outcome parameters showed similar results. Conclusion Patients' perception of health can be different with equal disease activity, depending on the moment in the disease course. Furthermore, our results indicate that self‐reported measures on functionality, disease activity, and general health cannot substitute for objective measures of disease activity in RA in longitudinal studies; subsequently, both need to be measured.
ISSN:0004-3591
0893-7524
1529-0131
1529-0123
DOI:10.1002/art.22225