Association of estrogen receptor α gene polymorphisms with bone mineral density in Chinese women : a meta-analysis

A large number studies have examined the association between estrogen receptor alpha (ESR-alpha) gene polymorphisms and bone mineral density (BMD) in the Chinese population. We conducted a meta-analysis to assess their pooled effects. We searched for all published articles indexed in MEDLINE, the Ch...

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Bibliographic Details
Published in:Osteoporosis international 2007-03, Vol.18 (3), p.295-305
Main Authors: WANG, C.-L, TANG, X.-Y, CHEN, W.-Q, SU, Y.-X, ZHANG, C.-X, CHEN, Y.-M
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Bone Density - genetics
China
Diseases of the osteoarticular system
Estrogen Receptor alpha - genetics
Female
Femur Neck - physiopathology
Genetic Predisposition to Disease
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lumbar Vertebrae - physiopathology
Medical sciences
Middle Aged
Osteoarticular system. Muscles
Osteoporosis - ethnology
Osteoporosis - genetics
Osteoporosis - physiopathology
Osteoporosis, Postmenopausal - ethnology
Osteoporosis, Postmenopausal - genetics
Osteoporosis, Postmenopausal - physiopathology
Osteoporosis. Osteomalacia. Paget disease
Polymorphism, Genetic
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:A large number studies have examined the association between estrogen receptor alpha (ESR-alpha) gene polymorphisms and bone mineral density (BMD) in the Chinese population. We conducted a meta-analysis to assess their pooled effects. We searched for all published articles indexed in MEDLINE, the Chinese Biomedical Database, and the Chinese Journal Full-text Database from January 1994 to April 2006. Any cross-sectional study that tested the association between ESR-alpha PvuII or XbaI genotypes and BMD at the femoral neck or spine in Chinese women was included in the review. Data were extracted independently by two reviewers using a standardized data extraction form. Sixteen eligible studies involving 4,297 Chinese women were identified. The overall frequencies of X and P alleles were 28% and 40%, respectively. The PvuII polymorphism was statistically significantly associated with BMD at the femoral neck (P = 0.038 for PP = Pp = pp) but not at the lumbar spine in all women. The BMD difference for the contrasts of PP versus Pp/pp genotypes was -0.0105 (95%CI, -0.0202 approximately -0.0008) g/cm(2) (P = 0.036). The XbaI polymorphism was not associated with BMD at the femoral neck or lumbar spine. The PvuII polymorphism had a very weak association with femoral neck BMD whereas XbaI polymorphism was unlikely to be a predictor of femoral neck or spine BMD in Chinese women.
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-006-0239-2