Intracellular and plasma efavirenz concentrations in HIV-infected patients switching from successful protease inhibitor-based highly active antiretroviral therapy (HAART) to efavirenz-based HAART (SUSTIPHAR Study)

Objectives: To assess intracellular and plasma efavirenz concentrations in HIV-infected patients who switched to efavirenz-based highly active antiretroviral therapy (HAART) from successful protease inhibitor-based HAART. Patients and methods: A total of 49 patients were included in this observation...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2006-11, Vol.58 (5), p.1090-1093
Main Authors: Djabarouti, Sarah, Breilh, Dominique, Pellegrin, Isabelle, Lavit, Michel, Camou, Fabrice, Caubet, Olivier, Fleury, Hervé, Saux, Marie-Claude, Pellegrin, Jean-Luc
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active - methods
Benzoxazines
Biological and medical sciences
Chemotherapy
Cohort Studies
drug efflux
drug metabolism
Female
HIV
HIV - genetics
HIV - isolation & purification
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - metabolism
HIV Protease Inhibitors - administration & dosage
HIV Protease Inhibitors - blood
HIV Protease Inhibitors - pharmacokinetics
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Middle Aged
Oxazines - administration & dosage
Oxazines - blood
Oxazines - pharmacokinetics
pharmacokinetics
Pharmacology
Pharmacology. Drug treatments
Protease inhibitors
Reverse Transcriptase Inhibitors - administration & dosage
Reverse Transcriptase Inhibitors - blood
Reverse Transcriptase Inhibitors - pharmacokinetics
RNA, Viral - blood
therapeutic drug monitoring
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Objectives: To assess intracellular and plasma efavirenz concentrations in HIV-infected patients who switched to efavirenz-based highly active antiretroviral therapy (HAART) from successful protease inhibitor-based HAART. Patients and methods: A total of 49 patients were included in this observational cohort study. At inclusion, all patients had plasma HIV-RNA levels
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkl348