Elevated salivary endothelin levels in oral cancer patients—A pilot study

Summary The analysis of saliva has been proposed as a potentially rapid, non-invasive method to monitor and diagnose patients with oral disease. In this study we measured salivary endothelin-1 (ET-1) levels in patients diagnosed with oral squamous cell carcinoma (SCC) prior to treatment. We demonstr...

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Bibliographic Details
Published in:	Oral oncology 2007-01, Vol.43 (1), p.37-41
Main Authors:	Pickering, Victoria, Jordan, Richard C.K, Schmidt, Brian L
Format:	Article
Language:	eng
Subjects:	Adult Aged Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Endothelin Endothelin-1 - analysis Enzyme-Linked Immunosorbent Assay ET-1 Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Leukoplakia, Oral - diagnosis Leukoplakia, Oral - metabolism Male Medical sciences Middle Aged Mouth Neoplasms - diagnosis Mouth Neoplasms - metabolism Oral cancer Oral squamous cell carcinoma Otolaryngology Otorhinolaryngology. Stomatology Pilot Projects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Saliva Saliva - chemistry Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:	Summary The analysis of saliva has been proposed as a potentially rapid, non-invasive method to monitor and diagnose patients with oral disease. In this study we measured salivary endothelin-1 (ET-1) levels in patients diagnosed with oral squamous cell carcinoma (SCC) prior to treatment. We demonstrate significantly elevated salivary ET-1 levels in the oral SCC group (4.37 ± 1.35 pg/ml), relative to the control group (1.16 ± 0.29 pg/ml). ET-1 and ET-1 mRNA were also measured in oral SCC tissue specimens and compared to normal oral epithelial controls. The concentration of ET-1 in the oral SCC specimens was 17.87 ± 4.0 pg/ml and in the normal epithelial controls the concentration of ET-1 was 5.43 ± 2.5 pg/ml. ET-1 mRNA was significantly overexpressed in 80% (8/10) of the oral SCC specimens. Our results demonstrate the potential utility of salivary analysis for ET-1 levels to monitor patients at risk for oral SCC.
ISSN:	1368-8375 1879-0593